- MCL-1 MODULATING COMPOSITIONS
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The present invention relates to marinopyrrole A derivatives and pyoluteorin derivatives and methods of treatment of disorders associated with misregulation of Mcl-l, e.g., leukemia, lymphoma, multiple myeloma, melanoma, or pancreatic cancer. We describe exemplary compounds, which may be contained in pharmaceutical compositions, and their use as therapeutic agents either alone or in combination with other anti-cancer treatments, e.g., anti-Bcl- 2 agents.
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Page/Page column 33; 34; 35; 52; 53
(2013/08/15)
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- Total synthesis of acortatarin A using a Pd(II)-catalyzed spiroketalization strategy
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The total synthesis of acortatarin A relying on a Pd(II)-catalyzed spiroketalization is reported. This strategy allows a single stereocenter in the spiroketalization substrate to produce the target efficiently under mild conditions, installing the necessa
- Borrero, Nicholas V.,Aponick, Aaron
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p. 8410 - 8416,7
(2020/09/15)
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- Total synthesis of (±)-marinopyrrole a via copper-mediated N-arylation
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The total synthesis of the racemic form of the marine alkaloid marinopyrrole A is described. The characteristic 1,3′-bipyrrole core was constructed by a copper-mediated N-arylation process under microwave irradiation.
- Kanakis, Argyrios A.,Sarli, Vasiliki
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supporting information; experimental part
p. 4872 - 4875
(2011/02/22)
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- Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems
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(Matrix presented) Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.
- Ruiz, Javier,Sotomayor, Nuria,Lete, Esther
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p. 1115 - 1117
(2007/10/03)
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- Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
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Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picomaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
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