368211-06-7

Usage

Derivative of pyrrole

A five-membered aromatic heterocycle The compound is based on a pyrrole structure, which is a five-membered ring containing one nitrogen atom and four carbon atoms.

Carboxamide functional group

A nitrogen atom with an attached amide group The compound contains an amide group (C=O) bonded to a nitrogen atom, which is a common functional group in organic synthesis and medicinal chemistry.

Methoxy and methyl substituents

Two organic groups attached to the nitrogen atom A methoxy group (-OCH3) and a methyl group (-CH3) are present on the nitrogen atom, which can influence the compound's reactivity and properties.

Building block in organic synthesis

Versatile starting material for creating more complex molecules The compound can be used as a starting material to synthesize a variety of more complex organic molecules, making it valuable in research and industrial applications.

Medicinal chemistry applications

Potential use in the development of pharmaceuticals Due to its unique structure and functional groups, 1H-Pyrrole-2-carboxamide, N-methoxy-N-methyl (9CI) may be used in the design and synthesis of new drugs and therapeutic agents.

Upstream product

• 634-97-9 pyrrole-2-carboxyl acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 79-37-8 oxalyl dichloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 109-97-7 pyrrole 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 

Downstream Products

• 524024-80-4 1-(2-iodobenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 524024-82-6 1-(2-iodo-5-methoxybenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 524024-81-5 1-(2-iodo-4,5-dimethylbenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 524024-84-8 1-(6-iodo-2,3-dimethoxybenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 524024-83-7 1-(2-iodo-4,5-dimethoxybenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 524024-86-0 1-(2-iodo-3,4,5-trimethoxybenzyl)pyrrole-2-carboxylic acid methoxy methyl amide 
• 851384-98-0 1-[3-(2-iodo-4,5-dimethoxyphenyl)-propyl]-pyrrole-2-carboxylic acid methoxy methyl amide 
• 851384-97-9 1-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-pyrrole-2-carboxylic acid methoxy methyl amide 
• 51491-78-2 pyrrolo[1,2-b]isoquinolin-10(5H)-one 
• 1222465-76-0 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methoxymethylamide 
• 1401113-04-9 (2R,4S,5R)-4-(benzyloxy)-N-methoxy-N-methyl-5-vinyl-1',4,4',5-tetrahydro-3H-spiro[furan-2,3'-pyrrolo[2,1-c][1,4]-oxazine]-6'-carboxamide 
• 1401113-17-4 (2S,4S,5R)-4-(benzyloxy)-N-methoxy-N-methyl-5-vinyl-1',4,4',5-tetrahydro-3H-spiro[furan-2,3'-pyrrolo[2,1-c][1,4]-oxazine]-6'-carboxamide 
• 1401113-18-5 (2S,4S,5R)-4-(benzyloxy)-5-(hydroxymethyl)-N-methoxy-Nmethyl-1',4,4',5-tetrahydro-3H-spiro[furan-2,3'-pyrrolo[2,1-c]-[1,4]oxazine]-6′-carboxamide 
• 1401113-14-1 (2R,4S,5R)-4-(benzyloxy)-5-(hydroxymethyl)-N-methoxy-Nmethyl-1',4,4',5-tetrahydro-3H-spiro[furan-2,3'-pyrrolo[2,1-c]-[1,4]oxazine]-6′-carboxamide 

Relevant academic research and scientific papers

MCL-1 MODULATING COMPOSITIONS

The present invention relates to marinopyrrole A derivatives and pyoluteorin derivatives and methods of treatment of disorders associated with misregulation of Mcl-l, e.g., leukemia, lymphoma, multiple myeloma, melanoma, or pancreatic cancer. We describe exemplary compounds, which may be contained in pharmaceutical compositions, and their use as therapeutic agents either alone or in combination with other anti-cancer treatments, e.g., anti-Bcl- 2 agents.

Total synthesis of acortatarin A using a Pd(II)-catalyzed spiroketalization strategy

The total synthesis of acortatarin A relying on a Pd(II)-catalyzed spiroketalization is reported. This strategy allows a single stereocenter in the spiroketalization substrate to produce the target efficiently under mild conditions, installing the necessa

Total synthesis of (±)-marinopyrrole a via copper-mediated N-arylation

The total synthesis of the racemic form of the marine alkaloid marinopyrrole A is described. The characteristic 1,3′-bipyrrole core was constructed by a copper-mediated N-arylation process under microwave irradiation.

Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems

(Matrix presented) Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.

Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picomaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.