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2-Amino-4-bromoquinoline, a heterocyclic aromatic amine with the molecular formula C9H7BrN2, is a chemical compound that features a bromine substituent. It is known for its potential carcinogenic and mutagenic properties, which necessitates careful handling and use in laboratory and industrial settings. Moreover, it has been explored for its biological activity and potential therapeutic applications in drug discovery and development.

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  • 36825-32-8 Structure
  • Basic information

    1. Product Name: 2-AMINO-4-BROMOQUINOLINE
    2. Synonyms: 2-AMINO-4-BROMOQUINOLINE;4-Bromoquinolin-2-amine;4-Bromo-2-quinolinamine;4-Bromoquinolin-2-amine, 2-Amino-4-bromo-1-azanaphthalene
    3. CAS NO:36825-32-8
    4. Molecular Formula: C9H7BrN2
    5. Molecular Weight: 223.06928
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 36825-32-8.mol
  • Chemical Properties

    1. Melting Point: 137-138℃
    2. Boiling Point: 359℃
    3. Flash Point: 171℃
    4. Appearance: /
    5. Density: 1.649
    6. Vapor Pressure: 2.51E-05mmHg at 25°C
    7. Refractive Index: 1.732
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. PKA: 5.01±0.50(Predicted)
    11. CAS DataBase Reference: 2-AMINO-4-BROMOQUINOLINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-AMINO-4-BROMOQUINOLINE(36825-32-8)
    13. EPA Substance Registry System: 2-AMINO-4-BROMOQUINOLINE(36825-32-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 36825-32-8(Hazardous Substances Data)

36825-32-8 Usage

Uses

Used in Pharmaceutical Synthesis:
2-Amino-4-bromoquinoline is utilized as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable building block for the development of new drugs.
Used in Dye and Pigment Production:
In the chemical industry, 2-Amino-4-bromoquinoline serves as a crucial component in the production of dyes and pigments. Its ability to impart color and stability to these products makes it an essential ingredient in various applications.
Used in Drug Discovery and Development:
Due to its biological activity, 2-Amino-4-bromoquinoline has been investigated for its potential therapeutic applications in drug discovery and development. Researchers are exploring its properties to identify new avenues for treating various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 36825-32-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,2 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 36825-32:
(7*3)+(6*6)+(5*8)+(4*2)+(3*5)+(2*3)+(1*2)=128
128 % 10 = 8
So 36825-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7BrN2/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5H,(H2,11,12)

36825-32-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-bromoquinolin-2-amine

1.2 Other means of identification

Product number -
Other names 4-Bromo-2-quinolinamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36825-32-8 SDS

36825-32-8Downstream Products

36825-32-8Relevant articles and documents

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

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Page/Page column 81, (2019/05/22)

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

QUINOLINE-BASED KINASE INHIBITORS

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Page/Page column 105-106, (2015/11/02)

The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.

Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands

Verheij, Mark H. P.,Thompson, Andrew J.,Van Muijlwijk-Koezen, Jacqueline E.,Lummis, Sarah C. R.,Leurs, Rob,De Esch, Iwan J. P.

, p. 8603 - 8614 (2013/01/15)

The 5-HT3 receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therapeutic target. During a recent fragment screen, 6-chloro-N-methyl-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine (1) was identified as a 5-HT3R hit fragment. Here we describe the synthesis and structure-activity relationships (SAR) of a series of (iso)quinoline and quinazoline compounds that were synthesized and screened for 5-HT3R affinity using a [3H]granisetron displacement assay. These studies resulted in the discovery of several high affinity ligands of which compound 22 showed the highest affinity (pKi > 10) for the 5-HT3 receptor. The observed SAR is in agreement with established pharmacophore models for 5-HT3 ligands and is used for ligand-receptor binding mode prediction using homology modeling and in silico docking approaches.

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