42712-64-1

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4-HYDROXYQUINOLINE HYDRATE is used as a key intermediate in the synthesis of various quinazoline and quinazoline derivatives. These derivatives are important for the development of new drugs and pharmaceutical compounds, as they possess a wide range of biological activities, including anti-cancer, anti-inflammatory, and anti-microbial properties.
Used in Chemical Research:
In the field of chemical research, 2-AMINO-4-HYDROXYQUINOLINE HYDRATE serves as a valuable reagent for the preparation of quinazoline-based compounds. These compounds are of significant interest due to their diverse applications in medicinal chemistry, materials science, and other related fields.
Used in Organic Synthesis:
2-AMINO-4-HYDROXYQUINOLINE HYDRATE is also utilized in organic synthesis as a building block for the creation of more complex organic molecules. Its unique functional groups allow for various chemical reactions, enabling the synthesis of a wide array of compounds with potential applications in different industries.

InChI:InChI=1/C9H8N2O/c10-9-5-8(12)6-3-1-2-4-7(6)11-9/h1-5H,(H3,10,11,12)

Upstream product

• 42712-65-2 4-methoxyquinolin-2-ylamine 
• 610-14-0 2-nitrobenzyl chloride 
• 118-48-9 isatoic anhydride 
• 109-77-3 malononitrile 
• 62-53-3 aniline 
• 105-56-6 ethyl 2-cyanoacetate 
• 90303-35-8 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoyl chloride 
• 4336-70-3 (cyanomethyl)triphenylphosphonium chloride 
• 91974-26-4 2-cyano-3-(2-nitro-phenyl)-3-oxo-propionic acid ethyl ester 

Downstream Products

• 42712-65-2 4-methoxyquinolin-2-ylamine 
• 36825-32-8 2-amino-4-bromoquinoline 
• 1085412-36-7 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine 
• 1393488-62-4 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine 
• 1472611-44-1 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate) 
• 14933-24-5 3-bromo-quinoline-2,4-diol 
• 491-36-1 4-Hydroxyquinazoline 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 5651-01-4 2-(oxalamino)benzoic acid 
• 20151-42-2 4-chloro-quinolin-2-ylamine 

Relevant academic research and scientific papers

QUINOLINE-BASED KINASE INHIBITORS

The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.

Remarkably efficient and direct route to quinolines and benzoazepines from the condensation of benzoxazinediones with phosphonium carbanion salts

Treatment of 2H-3,1-benzoxazine-2,4(1H)-dione (1a) with vinyltriphenylphosphonium bromide (2a) gives substituted benzoazepine 8a (48% yield) and indolizinone 12 (27% yield), whereas substituted quinolinone 15 and benzoazepine 8b were isolated from the rea

Process for making 2-amino-4-hydroxyquinolines

The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-α,α-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

2-Amino-3-cyano-4-hydroxyquinolines

The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxyquinolines and 2-amino-α,α-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.