42712-64-1

Basic information

• Product Name: 2-AMINO-4-HYDROXYQUINOLINE HYDRATE
• Synonyms: 2-AMinoquinolin-4(1H)-one;2-Amino-4-quinolinol;2-AMINOQUINOLIN-4-OL;2-AMINO-4-HYDROXYQUINOLINE;2-AMINO-4-HYDROXYQUINOLINE HYDRATE;2-amino-4-quinolino;2-Aminoquinolinol hydrate;2-AMINO-4-HYDROXYQUINOLINE HYDRATE 97%
• CAS NO: 42712-64-1
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• EINECS: -0
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Quinolines
• Mol File: 42712-64-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 294.1 °C at 760 mmHg
• Flash Point: 131.7 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.63±0.40(Predicted)
• BRN: 124785
• CAS DataBase Reference: 2-AMINO-4-HYDROXYQUINOLINE HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-HYDROXYQUINOLINE HYDRATE(42712-64-1)
• EPA Substance Registry System: 2-AMINO-4-HYDROXYQUINOLINE HYDRATE(42712-64-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 42712-64-1(Hazardous Substances Data)

Usage

Uses

2-Aminoquinolin-4-ol is a useful reagent used in the preparation of quinazolines and quinazolines derivatives.

InChI:InChI=1/C9H8N2O/c10-9-5-8(12)6-3-1-2-4-7(6)11-9/h1-5H,(H3,10,11,12)

Upstream product

• 118-48-9 isatoic anhydride 
• 109-77-3 malononitrile 
• 62-53-3 aniline 
• 105-56-6 ethyl 2-cyanoacetate 
• 610-14-0 2-nitrobenzyl chloride 
• 90303-35-8 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoyl chloride 
• 4336-70-3 (cyanomethyl)triphenylphosphonium chloride 
• 91974-26-4 2-cyano-3-(2-nitro-phenyl)-3-oxo-propionic acid ethyl ester 
• 42712-65-2 4-methoxyquinolin-2-ylamine 

Downstream Products

• 14933-24-5 3-bromo-quinoline-2,4-diol 
• 36825-32-8 2-amino-4-bromoquinoline 
• 42712-65-2 4-methoxyquinolin-2-ylamine 
• 1085412-36-7 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine 
• 1393488-62-4 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine 
• 1472611-44-1 4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate) 
• 491-36-1 4-Hydroxyquinazoline 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 5651-01-4 2-(oxalamino)benzoic acid 
• 20151-42-2 4-chloro-quinolin-2-ylamine 

Relevant articles and documents

QUINOLINE-BASED KINASE INHIBITORS

The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.

Process for making 2-amino-4-hydroxyquinolines

The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-α,α-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.