371219-74-8

Basic information

• Product Name: 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE
• Synonyms: 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE;2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide
• CAS NO: 371219-74-8
• Molecular Formula: C14H15ClN2O
• Molecular Weight: 262.73
• Mol File: 371219-74-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE(371219-74-8)
• EPA Substance Registry System: 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE(371219-74-8)

Safety Data

• Hazardous Substances Data: 371219-74-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE is used as a potential antipsychotic agent for the treatment of various psychiatric disorders. Its unique chemical structure and pharmacological properties are being studied to understand its efficacy and safety in managing symptoms associated with mental health conditions.
Used in Research and Development:
In the field of medicinal chemistry, 2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE serves as a valuable compound for research and development. Scientists and researchers utilize this compound to explore its potential interactions with biological targets, such as neurotransmitter receptors, and to investigate its role in modulating neurochemical pathways implicated in psychiatric disorders. This research aims to advance the understanding of the compound's therapeutic potential and to contribute to the development of novel antipsychotic drugs.

Upstream product

• 871586-90-2 methyl 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylate 
• 52784-32-4 2-(methoxycarbonyl)cycloheptanone 
• 871586-89-9 methyl 3-bromo-2-oxo-1-cycloheptanecarboxylate 

Downstream Products

• 848193-72-6 (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide 
• 848193-72-6 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING MALARIA OR LEISHMANIASIS

Compounds, compositions and methods for the treatment of malaria and/or leishmaniasis are described herein.

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1

High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing enzymes. The most potent compounds described herein inhibit SIRT1 with IC50 values of 60-100 nM, representing a 500-fold improvement over previously reported SIRT inhibitors. Preparation of enantiomerically pure indole derivatives allowed for their characterization in vitro and in vivo. Kinetic analyses suggest that these inhibitors bind after the release of nicotinamide from the enzyme and prevent the release of deacetylated peptide and O-acetyl-ADP-ribose, the products of enzyme-catalyzed deacetylation. These SIRT1 inhibitors are low molecular weight, cell-permeable, orally bioavailable, and metabolically stable. These compounds provide chemical tools to study the biology of SIRT1 and to explore therapeutic uses for SIRT1 inhibitors.