372093-36-2

Basic information

• Product Name: 2-chloro-N-(3-ethylphenyl)-5-nitrobenzamide
• Synonyms: 2-chloro-N-(3-ethylphenyl)-5-nitrobenzamide
• CAS NO: 372093-36-2
• Molecular Formula: C₁₅H₁₃ClN₂O₃
• Molecular Weight: 304.72832
• Mol File: 372093-36-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-N-(3-ethylphenyl)-5-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(3-ethylphenyl)-5-nitrobenzamide(372093-36-2)
• EPA Substance Registry System: 2-chloro-N-(3-ethylphenyl)-5-nitrobenzamide(372093-36-2)

Safety Data

• Hazardous Substances Data: 372093-36-2(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 587-02-0 m-ethylaniline 

Relevant articles and documents

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

The risk of cardiovascular events increases in individuals with elevated plasma triglyceride (TG) levels, therefore advocating the need for efficient TG-lowering drugs. In the blood circulation, TG levels are regulated by lipoprotein lipase (LPL), an unstable enzyme that is only active as a non-covalently associated homodimer. We recently reported on a N-phenylphthalimide derivative (1) that stabilizes LPL in vitro, and moderately lowers triglycerides in vivo (Biochem. Biophys. Res. Commun. 2014, 450, 1063). Herein, we establish structure-activity relationships of 51 N-phenylphthalimide analogs of the screening hit 1. In vitro evaluation highlighted that modifications on the phthalimide moiety were not tolerated and that lipophilic substituents on the central phenyl ring were functionally essential. The substitution pattern on the central phenyl ring also proved important to stabilize LPL. However, in vitro testing demonstrated rapid degradation of the phthalimide fragment in plasma which was addressed by replacing the phthalimide scaffold with other heterocyclic fragments. The in vitro potency was retained or improved and substance 80 proved stable in plasma and efficiently lowered plasma TGs in vivo.

PPAR-gamma modulator

A compound of the following formula or a pharmacologically acceptable salt thereof: 1 wherein A represents a phenyl group or the like, B represents an aryl group or the like, X represents an oxygen atom or the like, and n represents 0 or 1. The compound is a PPAR γ modulator which is a therapeutic agent for retrograde osteoporosis in which excessive differentiation of adipocytes is inhibited and formation and differentiation of osteoblasts from stem cells is facilitated, and for diabetes mellitus without characteristics such as excessive adipogenesis, liver dysfunction, vascular disorders, heart diseases and the like.