372171-37-4

Basic information

• Product Name: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)
• Synonyms: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI);5-Acetyl-4-(4-fluorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one
• CAS NO: 372171-37-4
• Molecular Formula: C13H13FN2O2
• Molecular Weight: 248.2529232
• Product Categories: BIGNELLI
• Mol File: 372171-37-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)(372171-37-4)
• EPA Substance Registry System: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)(372171-37-4)

Safety Data

• Hazardous Substances Data: 372171-37-4(Hazardous Substances Data)

Usage

Structure

2(1H)-Pyrimidinone derivative with an acetyl group at position 5, a 4-fluorophenyl group at position 4, and a 3,4-dihydro and 6-methyl group.

Appearance

White to off-white solid

Use

Pharmaceutical intermediate in the synthesis of other organic compounds

Potential biological activities

May be used in the development of drugs for various medical conditions

Precautions

Potential health hazards and environmental risks, handle with caution.

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 57-13-6 urea 
• 123-54-6 acetylacetone 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Synthesis method of dihydropyrimidinone compound

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

Exploiting silver trifluoromethanesulfonate as efficient and reusable catalyst for the synthesis of dihydropyrimidine derivatives under different reaction environments

Different results were generated under different reaction conditions for the multicomponent reactions. Herein, an efficiently improved and mild protocol for the synthesis of dihydropyrimidine derivatives using cheap silver trifluoromethanesulfonate (CFsu

SnO2 nanoparticles: An efficient reusable heterogeneous catalyst for synthesis of 3,4-dihydropyrimidinones under solvent-free conditions

Some 3,4-dihydropyrimidine derivatives have been synthesized from the reaction of divergent aldehydes with acetylacetone and urea/thiourea using nano tin oxide nanoparticles under solvent-free condition. The nanoparticle catalyst used in this synthesis is

Polyaniline Supported FeCl3: An Effective Heterogeneous Catalyst for Biginelli Reaction

Abstract: Polyaniline supported FeCl3 is prepared and tested as an efficient heterogeneous Lewis acidic catalyst for the Biginelli reaction. The catalyst PANI–FeCl3 shows excellent activity in the synthesis of dihydropyrimidinones fr

Sulfamic Acid Supported Magnetic Fe3O 4 Nanoparticles Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1 H)-ones/Thiones

Sulfamic acid supported on magnetic Fe3O4 nanoparticles catalyzed the condensation reaction of aldehydes, 1,3-dicarbonyl compounds, and urea or thiourea in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free c

Boehmite nanoparticle catalyst for the one-pot multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones under solvent-free conditions

A simple, green, and efficient synthesis protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones using boehmite nanoparticles as catalyst was developed. It did not use any toxic metal catalysts or corrosive acidic reagents. The method gave good to excellent yields and has short reaction time, operational simplicity, and a recyclable catalyst.

Boron trioxide-alumina as a heterogeneous catalyst in a facile solvent free one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones

B2O3/Al2O3 has been found to be a new and highly efficient heterogeneous catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by the Biginelli reaction under solvent-free conditions. 3,4-Dihydropyrimidin-2(1H)-ones have important pharmacological and biological activities.

Synthesis of Biginelli compounds using cobalt hydrogen sulfate

Efficient synthesis of various 2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidines containing acetyl, carboethoxy, carbomethoxy and carboxamide groups on 5-position of the M-substituted and ATL-unsubstituted heterocyclic ring was achieved using cobalt hydrogen su

Highly efficient solvent-free synthesis of dihydropyrimidinones catalyzed by zinc oxide

A simple, efficient and practical procedure for the Biginelli reaction using zinc oxid (ZnO) as a novel and reusable catalyst is described under solvent-free conditions in high yields. The use of this agent is characterized by remarkable reactivity, moder