2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)

Base Information

• Chemical Name: 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)
• CAS No.: 372171-37-4
• Molecular Formula: C₁₃H₁₃FN₂O₂
• Molecular Weight: 248.257
• Mol file: 372171-37-4.mol

Synonyms:2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)

Chemical Property of 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)

Chemical Property:

• PSA: 61.69000
• LogP: 2.01140

Purity/Quality:

5-ACETYL-4-(4-FLUOROPHENYL)-6-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI)

There total 4 articles about 2(1H)-Pyrimidinone,5-acetyl-4-(4-fluorophenyl)-3,4-dihydro-6-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-fluorobenzaldehyde (459-57-4) + urea (57-13-6) + acetylacetone (123-54-6,81235-32-7) → 5‐acetyl‐4‐(4‐fluorophenyl)‐6‐methyl‐3,4‐dihydropyrimidin‐2(1H)‐one (372171-37-4)

Guidance literature:

With zinc(II) oxide; at 80 ℃; for 0.133333h; Solvent-free conditions;

DOI:10.1080/00397910802592874

Reference yield: 89.0%

4-fluorobenzylic alcohol (459-56-3) + urea (57-13-6) + acetylacetone (123-54-6,81235-32-7) → 5‐acetyl‐4‐(4‐fluorophenyl)‐6‐methyl‐3,4‐dihydropyrimidin‐2(1H)‐one (372171-37-4)

Guidance literature:

4-fluorobenzylic alcohol; With bismuth(III) nitrate; In acetonitrile; Heating;

urea; acetylacetone; In acetonitrile; Heating;

DOI:10.3987/COM-04-10257

Reference yield: 89.0%

→ 5‐acetyl‐4‐(4‐fluorophenyl)‐6‐methyl‐3,4‐dihydropyrimidin‐2(1H)‐one (372171-37-4)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; at 50 ℃; for 16h;

upstream raw materials:

4-fluorobenzaldehyde

urea

acetylacetone

1-chloromethyl-4-fluorobenzene