374899-60-2Relevant articles and documents
Facile synthesis and altered ionization efficiency of diverse N ε-alkyllysine-containing peptides
Chakraborty, Debjani,Islam, Kabirul,Luo, Minkui
, p. 1514 - 1516 (2012)
Protein lysine methylation is a biologically-important posttranslational modification. Given the increased use of alkyllysine-containing peptides to study protein methylation, we describe an efficient solid-phase synthesis to access various alkyllysine-containing peptides. As an exemplary application, we evaluated how ionization efficiency of the alkyllysine peptides affects mass spectrometric analysis.
A simple synthesis of 6-hydroxynorleucine based on the rearrangement of an N-nitrosodichloroacetamide
McCarthy, Blaine G.,Macarthur, Nicholas S.,Jakobsche, Charles E.
, p. 502 - 504 (2016/01/12)
6-Hydroxynorleucine is a versatile chemical intermediate that has found broad use in target-oriented syntheses of numerous biologically active molecules. Despite its widespread use, and despite the various strategies that have been reported for its prepar
Peptide compounds and their use as protease substrates
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, (2008/06/13)
This invention is directed generally to peptide compounds and salts, and particularly to peptide compounds and salts that are useful as protease substrates, such as matrix metalloprotease (“MMP”) substrates. This invention also is directed to methods for making such compounds and salts, as well as amino acids that may, for example, be used in such methods. This invention is further directed to methods for using such compounds and salts to, for example, evaluate the effectiveness of potential protease inhibitors and to detect or monitor a disease associated with protease activity.
