375345-97-4

Basic information

• Product Name: (R)-N-(2-phenylpropyl)propane-2-sulfonaMide
• Synonyms: (R)-N-(2-phenylpropyl)propane-2-sulfonaMide
• CAS NO: 375345-97-4
• Molecular Formula: C₁₂H₁₉NO₂S
• Molecular Weight: 241.34976
• Mol File: 375345-97-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-N-(2-phenylpropyl)propane-2-sulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(2-phenylpropyl)propane-2-sulfonaMide(375345-97-4)
• EPA Substance Registry System: (R)-N-(2-phenylpropyl)propane-2-sulfonaMide(375345-97-4)

Safety Data

• Hazardous Substances Data: 375345-97-4(Hazardous Substances Data)

Upstream product

• 1823-91-2 1-phenylethyl cyanide 
• 34298-25-4 (R)-β-methylphenethylamine hydrochloride 
• 20780-53-4 (R)-Styrene oxide 
• 685876-10-2 (2R)-2-phenylpropylamine Malate 
• 10147-37-2 Isopropylsulfonyl chloride 
• 582-22-9 (R)-2-phenylpropylamine 
• 112424-29-0 (R)-2-(2-phenylpropyl)isoindoline-1,3-dione 
• 1123-85-9 (+)-(R)-2-phenylpropanol 

Downstream Products

• 400629-36-9 propane-2-sulfonic acid {2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propyl}amide 

Relevant articles and documents

BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS

Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMP A receptors.

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

AMPA RECEPTOR POTENTIATORS

The present invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.

Sulfonamide derivatives

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.

Heterocyclic sulfonamide derivatives

The present invention provides certain heterocyclic sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Combination therapy for treatment of depression

The present invention provides a method for treating depression, comprising administering to a patient an effective amount of a first component which is a suitable antidepressant, in combination with an effective amount of a second component which is a suitable AMPA receptor potentiator.

Process for preparing biphenyl compounds

The present invention relates to a process for the preparation of a biphenyl compound comprising combining a phenyl boronic acid derivative with an halobenzene derivative in the presence of a suitable additive in a suitable organic solvent with a suitable catalyst and a suitable base.