582-22-9

Basic information

• Product Name: 2-PHENYLPROPYLAMINE
• Synonyms: RARECHEM AL BW 0191;1-AMINO-2-PHENYLPROPANE;2-PHENYLPROPYLAMINE;2-PHENYLPROPAN-1-AMINE;AKOS 236-27;AKOS BBS-00006774;BETA-METHYLPHENETHYLAMINE;ASISCHEM D19374
• CAS NO: 582-22-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• EINECS: 209-479-2
• Product Categories: Fine Chemical
• Mol File: 582-22-9.mol
• Article Data: 44

Chemical Properties

• Melting Point: 116°C (estimate)
• Boiling Point: 80 °C10 mm Hg(lit.)
• Flash Point: 175 °F
• Appearance: colorless liquid
• Density: 0.93 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.197mmHg at 25°C
• Refractive Index: n20/D 1.524(lit.)
• PKA: 9.92±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-PHENYLPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLPROPYLAMINE(582-22-9)
• EPA Substance Registry System: 2-PHENYLPROPYLAMINE(582-22-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• RTECS: SH9520000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 582-22-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

Different sources of media describe the Uses of 582-22-9 differently. You can refer to the following data:
1. 2-PHENYLPROPYLAMINE was used for molecular imprinting and to study the space filling models depicting minimized structures for each enantiomer 1 .
2. β-Methylphenethylamine was used for molecular imprinting and to study the space filling models depicting minimized structures for each enantiomer.

General Description

β-Methylphenethylamine is considered to be a positional isomer of amphetamine.

InChI:InChI=1/C9H13N/c1-8(7-10)9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/p+1/t8-/m1/s1

Upstream product

• 75-55-8 2-Methylaziridine 
• 7446-70-0 aluminium trichloride 
• 107-11-9 1-amino-2-propene 
• 71-43-2 benzene 
• 34713-70-7 2-Phenylpropanal 
• 34298-25-4 (R)-β-methylphenethylamine hydrochloride 
• 14182-57-1 (R)-2-phenylpropionic acid amide 
• 2328-26-9 methyl (R)-2-phenylpropanoate 
• 98-83-9 isopropenylbenzene 
• 1391911-23-1 (R)-4-methyl-N-(2-phenylpropyl)benzenesulfonamide 
• 137595-22-3 N-(4-tolylsulfonyl)-2-methyl-2-phenylaziridine 
• 58567-50-3 N-[2-(phenyl)prop-2-en-1-yl]-N-(p-toluenesulfonyl)amide 
• 1823-91-2 1-phenylethyl cyanide 
• 20780-53-4 (R)-Styrene oxide 

Downstream Products

• 1219-40-5 nicotinic acid-(2-phenyl-propylamide) 
• 17596-79-1 (2S)-2-phenyl-1-propanamine 
• 582-22-9 (R)-2-phenylpropylamine 
• 159212-33-6 3-[1-(2-Phenyl-propylamino)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 159212-33-6 3-[1-(2-Phenyl-propylamino)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one 
• 162662-88-6 2-(2-phenylpropyl)-1H-isoindole-1,3(2H)-dione 
• 26783-34-6 2-amino-N⁶-(2-phenyl-propyl)-adenosine 
• 124498-68-6 2-(2-phenylpropylamino)-adenosine 
• 109956-81-2 (2R,3S,4R,5R)-2-Hydroxymethyl-5-[6-(2-phenyl-propylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol 
• 149486-09-9 1-((R)-2-Phenyl-propyl)-3-thiazol-2-yl-thiourea 

Relevant articles and documents

CO2-Assisted asymmetric hydrogenation of prochiral allylamines

A new methodology for the asymmetric hydrogenation of allylamines takes advantage of a reversible reaction between amines and carbon dioxide (CO2) to suppress unwanted side reactions. The effects of various parameters (pressure, time, solvent, and base additives) on the enantioselectivity and conversion of the reaction were studied. The homogeneously-catalyzed asymmetric hydrogenation of 2-arylprop- 2-en-1-amine resulted in complete conversion and up to 82% enantiomeric excess (ee). Added base, if chosen carefully, improves the enantioselectivity and chemoselectivity of the overall reaction.

Iron-Catalyzed Diastereoselective Synthesis of Disubstituted Morpholines via C-O or C-N Bond Formation

The diastereoselective synthesis of 2,6- and 3,5-disubstituted morpholines was achieved from 1,2-amino ethers and 1,2-hydroxy amines substituted by an allylic alcohol using an iron(III) catalyst. The morpholines were obtained either by C-O or C-N bond formation. A plausible mechanism is suggested, involving a thermodynamic equilibrium to explain the formation of the cis diastereoisomer as the major product.

Quinazoline derivatives and its preparation method and application

The invention relates to quinazoline derivatives and its preparation method and application. The quinazoline derivatives with The structural formula, the quinazoline derivative to gefitinib for the positive control, the result shows that compared with the gefitinib has good activity; and lead compound OTS514 compared, equivalent activity, PBK/TOPK inhibitors for further transformation and the discovery of new anti-tumor medicine phenological shopping has higher learning with the reference value. The invention also provides a preparation method of the quinazoline derivatives and the preparation of PBK/TOPK inhibitor and an anticancer drug.