- SYNTHESIS OF N-(2,4-DINITROPHENYL)-4-NITROBENZAMIDE (TNBA) USING SOLID ACID CATALYSTS
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A method of making N-(2,4-dinitrophenyl)-4-nitrobenzamide from a mixture of 2,4-dinitroaniline, 4-nitrobenzoyl chloride, and solid acid catalyst in an organic solvent, wherein the solid acid catalyst is not soluble in the organic solvent, the solid acid c
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Paragraph 0043-0050
(2021/12/29)
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- Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity
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A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1–6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated significantly high inhibition capacities in a dose-dependent manner with IC50 values of 3.7 and 5.3 μM, respectively. These two compounds were also accompanied by no cytotoxicity at the studied concentrations (max 50 μM) in macrophages. Molecular docking analysis on iNOS revealed that compounds 5 and 6 bind to the enzyme more efficiently compared to other compounds due to having optimum number of nitro groups, orientations and polarizabilities. In addition, 5 and 6 demonstrated distinct regulatory mechanisms for the expression of the iNOS enzyme at the mRNA and protein levels. Specifically, both suppressed expressions of COX-2, IL-1β and TNF-α significantly, at 10 and 20 μM. However, only compound 6 significantly and considerably decreased LPS-induced secretion of IL-1β and TNF-α. These results suggest that compound 6 may be a multi-potent promising lead compound for further optimization in structure and as well as for in vivo validation studies.
- Tumer, Tugba B.,Onder, Ferah Comert,Ipek, Hande,Gungor, Tugba,Savranoglu, Seda,Tok, Tugba Taskin,Celik, Ayhan,Ay, Mehmet
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p. 129 - 139
(2016/12/22)
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- Synthesis method of amino substituted 2-phenylbenzimidazole derivative
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The invention relates to a synthesis method of an amino substituted 2-phenylbenzimidazole derivative. The method uses cheap and easily available nitro substituted benzoic acid compound and dinitraniline compound as the raw materials for condensation to obtain an amide compound, then catalytic hydrogenation is carried out, and simultaneously cyclization is conducted to obtain the benzimidazole derivative. The reaction is green and efficient, the operation is simple and the yield is excellent.
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Paragraph 0017
(2018/09/21)
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- Colorimetric detection of cyanide with N-nitrophenyl benzamide derivatives
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A series of structurally simple N-nitrophenyl benzamide derivatives have been developed as chemosensors toward cyanide in aqueous environment by taking advantage of the cyanide's strong affinity toward the acyl carbonyl carbon. The high selectivity of these compounds toward CN- makes it a practical system for monitoring CN- concentrations in aqueous samples.
- Sun, Yue,Wang, Guofeng,Guo, Wei
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experimental part
p. 3480 - 3485
(2009/08/15)
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- METHOD OF PREPARATION OF 2 prime , 4 prime , 4-TRINITROBENZANILIDE BY NITRATION OF MONO- AND DINITROBENZANILIDES IN NITRIC AND SULFURIC ACIDS.
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Nitration of 4-nitrobenzanilide by concentrated nitric acid at various temperatures (0-50 degree C) and molar component ratios (from 1:1 to 1:12) was studied. The course of the reaction was monitored with aid of thin-layer chromatography on Silufol plates
- Matveev,Levchenko,Kudryavtseva,Abramov
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p. 119 - 120
(2007/10/02)
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- Process for making 2-(4'-aminophenyl) 5-amino benzimidazole
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A process for preparing 2-(4'-aminophenyl) 5-amino benzimidazole, a known intermediate used in the synthesis of azo dyes, is disclosed wherein p-nitrobenzoic acid is condensed with aniline, and the N(4'-nitrobenzoyl) aniline produced is dinitrited to N(4'-nitrobenzoyl) 2,4-dinitroaniline; the latter is reduced to the corresponding triamine, which, upon cyclodehydration, results in the 2-(4'-aminophenyl) 5-amino benzimidazole.
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