37632-91-0

Usage

Uses

Used in Chemical Synthesis:
2'',4'',4-TRINITROBENZANILIDE is used as a chemical intermediate for the synthesis of various organic compounds and explosives. Its reactivity and sensitivity to heat, shock, and friction make it a valuable component in the production of these materials.
Used in Dye Manufacturing:
2'',4'',4-TRINITROBENZANILIDE is used as a key ingredient in the manufacture of dyes. Its chemical properties contribute to the color and stability of the dyes produced.
Used in Pharmaceutical Industry:
2'',4'',4-TRINITROBENZANILIDE is used as a raw material in the production of pharmaceuticals. Its chemical structure and reactivity enable the development of various pharmaceutical compounds.
Used in Rubber Chemicals Production:
2'',4'',4-TRINITROBENZANILIDE is used as a component in the production of rubber chemicals. Its properties enhance the performance and durability of rubber products.
Used in Explosive Production:
2'',4'',4-TRINITROBENZANILIDE is used as an ingredient in the production of various explosives, such as picric acid and trinitroaniline. Its explosive properties make it a valuable component in the development of these materials.
Used in Research and Development:
2'',4'',4-TRINITROBENZANILIDE is used as a research compound in the study of chemical reactions and properties. Its mutagenicity and sensitivity to various stimuli make it an important subject for scientific investigation.

InChI:InChI=1/C13H8N4O7/c18-13(8-1-3-9(4-2-8)15(19)20)14-11-6-5-10(16(21)22)7-12(11)17(23)24/h1-7H,(H,14,18)

Upstream product

• 6333-15-9 4,4'-dinitrobenzanilide 
• 3460-11-5 4-nitrobenzanilide 
• 122-04-3 4-nitro-benzoyl chloride 
• 97-02-9 2,4-Dinitroanilin 
• 33490-01-6 4-nitro-N-(2-nitrophenyl)benzamide 
• 7697-37-2 nitric acid 
• 62-23-7 4-nitro-benzoic acid 
• 62-53-3 aniline 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 7621-86-5 2-(4-aminophenyl)-5-amino-benzimidazole 
• 60779-50-2 2',4',4-Triaminobenzanilide 
• 29955-49-5 4-Nitro-benzoesaeure-(2,4-dinitro-phenylimid)-chlorid 
• 91358-40-6 terabutylammnonium salt of 2',4,4'-trinitrobenzanilide 
• 91358-43-9 potassium salt of 2',4,4'-trinitrobenzanilide 

Relevant academic research and scientific papers

SYNTHESIS OF N-(2,4-DINITROPHENYL)-4-NITROBENZAMIDE (TNBA) USING SOLID ACID CATALYSTS

A method of making N-(2,4-dinitrophenyl)-4-nitrobenzamide from a mixture of 2,4-dinitroaniline, 4-nitrobenzoyl chloride, and solid acid catalyst in an organic solvent, wherein the solid acid catalyst is not soluble in the organic solvent, the solid acid c

Synthesis method of amino substituted 2-phenylbenzimidazole derivative

The invention relates to a synthesis method of an amino substituted 2-phenylbenzimidazole derivative. The method uses cheap and easily available nitro substituted benzoic acid compound and dinitraniline compound as the raw materials for condensation to obtain an amide compound, then catalytic hydrogenation is carried out, and simultaneously cyclization is conducted to obtain the benzimidazole derivative. The reaction is green and efficient, the operation is simple and the yield is excellent.

Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity

A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1–6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated significantly high inhibition capacities in a dose-dependent manner with IC50 values of 3.7 and 5.3 μM, respectively. These two compounds were also accompanied by no cytotoxicity at the studied concentrations (max 50 μM) in macrophages. Molecular docking analysis on iNOS revealed that compounds 5 and 6 bind to the enzyme more efficiently compared to other compounds due to having optimum number of nitro groups, orientations and polarizabilities. In addition, 5 and 6 demonstrated distinct regulatory mechanisms for the expression of the iNOS enzyme at the mRNA and protein levels. Specifically, both suppressed expressions of COX-2, IL-1β and TNF-α significantly, at 10 and 20 μM. However, only compound 6 significantly and considerably decreased LPS-induced secretion of IL-1β and TNF-α. These results suggest that compound 6 may be a multi-potent promising lead compound for further optimization in structure and as well as for in vivo validation studies.

Colorimetric detection of cyanide with N-nitrophenyl benzamide derivatives

A series of structurally simple N-nitrophenyl benzamide derivatives have been developed as chemosensors toward cyanide in aqueous environment by taking advantage of the cyanide's strong affinity toward the acyl carbonyl carbon. The high selectivity of these compounds toward CN- makes it a practical system for monitoring CN- concentrations in aqueous samples.

METHOD OF PREPARATION OF 2 prime , 4 prime , 4-TRINITROBENZANILIDE BY NITRATION OF MONO- AND DINITROBENZANILIDES IN NITRIC AND SULFURIC ACIDS.

Nitration of 4-nitrobenzanilide by concentrated nitric acid at various temperatures (0-50 degree C) and molar component ratios (from 1:1 to 1:12) was studied. The course of the reaction was monitored with aid of thin-layer chromatography on Silufol plates

Process for making 2-(4'-aminophenyl) 5-amino benzimidazole

A process for preparing 2-(4'-aminophenyl) 5-amino benzimidazole, a known intermediate used in the synthesis of azo dyes, is disclosed wherein p-nitrobenzoic acid is condensed with aniline, and the N(4'-nitrobenzoyl) aniline produced is dinitrited to N(4'-nitrobenzoyl) 2,4-dinitroaniline; the latter is reduced to the corresponding triamine, which, upon cyclodehydration, results in the 2-(4'-aminophenyl) 5-amino benzimidazole.