- A new amide compounds
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The invention provides a novel compound (as shown in the formula I) and salt thereof. Experimental results show that the novel compound can be applied to treating and preventing cerebral ischemic diseases and improving sleep; the novel amide compound can generate salt with alkali metal sodium, magnesium, kalium, calcium, organic base tris, diethyl amine, triethylamine and the like and has the functions of treating and preventing ischemic cardiovascular and cerebrovascular diseases and improving sleep.
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Paragraph 0013-0015
(2017/03/14)
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- Studies on the synthesis and bioactivities of 4-amino derivatives of tetramic acid
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In order to study the potential bioactivities of 4-amino tetramic acid derivatives, the 4-amination products of pyrrolidine-2,4-diones (5) and 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylates (4) were prepared. The 4-amination of 5 took place in high yield when catalyzed by acetic acid, whereas the 4-amination of 4 was achieved through a 4-ethoxy intermediate, which was prepared by acidic etherification. Their herbicidal, fungicidal, insecticidal, and antitumor activities were tested. The bioassays showed that two of the compounds exhibited good herbicidal activity against dicot Arabidopsis thaliana at a concentration of 10 μg/mL, and one compound gave instinct fungicidal activity against Pythium sp. at a concentration of 2 μg/mL.
- Liu, Yu-Xiu,Zhao, Hua-Ping,Song, Hai-Bin,Gu, Yu-Cheng,Wang, Qing-Min
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- REMEDY FOR DIABETES
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A method of screening a compound having a hypoglycemic effect (hereinafter referred to as "hypoglycemic compound"), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
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Page/Page column 22
(2010/04/23)
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- Tetramic acids as scaffolds: Synthesis, tautomeric and antibacterial behaviour
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Efficient synthetic routes for tetramic acids variously substituted on the ring nitrogen, their tautomeric behaviour in solution and their antibiotic activity are reported.
- Jeong, Yong-Chul,Moloney, Mark G.
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scheme or table
p. 2487 - 2491
(2010/03/01)
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- LACTAM COMPOUNDS AND MEDICINAL USE THEREOF
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An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
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- Dihydronaphthyridine potassium channel openers
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Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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- Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor
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The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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- Inhibitors of the advanced glycosylation of proteins and methods of use therefor
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The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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- 3-(heteroarylalkyene)- and 3-(arylalkylene)-2,4(3H,5H)-heterocyclic diones as cancer chemotherapy drugs
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Heterocyclic diones of the class containing 3-(heteroarylalkylene)- and 3(arylalkylene)-2, 4 (3H, 5H)-furandiones, and 3-(heteroarylalkylene)-pyrrolidene diones and -thiophene diones are disclosed as being effective cancer chemotherapy drugs, some of whic
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- Synthesis of tetramic acid
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4-Benzyloxy-3-pyrrolin-2-one is a new valuable intermediate product for the production of tetramic acid. Processes are described for the production of such intermediate as well as the production of tetramic acid.
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- A NOVEL SYNTHETIC METHOD OF LACTAMS FROM 1,3-DIOXIN-4-ONES VIA INTRAMOLECULAR KETENE TRAPPING
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A novel route to four- and five-membered lactams from 1,3-dioxin-4-ones having an α-aminoalkyl side-chain at 5- or 6-position through cycloreversion to acylketenes followed by intramolecular ketene trapping by the amino function is described.
- Sato, Masayuki,Ogasawara, Hiromichi,Takayama, Kazuhisa,Kaneko, Chikara
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p. 2611 - 2614
(2007/10/02)
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