QSAR study for a novel series of ortho monosubstituted phenoxy analogues of α1-adrenoceptor antagonist WB4101
A number of (S)- and (R)-2-[(2-phenoxyethyl)aminomethyl]-1,4-benzodioxanes unsubstituted or ortho monosubstituted at the phenoxy moiety were synthesized and tested in binding assays on the α1a-AR, α1b-AR, α1d-AR and the 5-
BICYCLIC HETEROCYCLIC DERIVATIVES HAVING ALPHA1 ADRENERGIC AND 5HT1A ACTIVITIES
This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding α 1-adrenergic and 5HT. sub.1A serotonergic receptors, in vitro or in vivo.
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(2008/06/13)
BICYCLIC HETEROCYCLIC DERIVATIVES HAVING ALPHA1-ADRENERGIC AND 5HT1 ALPHA
This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding α
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(2008/06/13)
3-Indenyl-γ-(ketobutyric)-acid compounds
New substituted indene acids and non-toxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indene acids disclosed herein have anti-inflammatory, anti-pyretic and analgesic activity. Also included herein are methods
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(2008/06/13)
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