The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists.
Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Chung, Janice,Reyes-Manalo, Grace,Kamenecka, Theodore
p. 1197 - 1200
(2007/10/03)
BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
The present invention is directed to novel amides such as those of Formula (I): (I) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood
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Page/Page column 47
(2008/06/13)
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