- MONOETHYLENICALLY UNSATURATED MONOMERS AND USES THEREOF
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The invention relates to a monoethylenically unsaturated monomer of formula (I), and to the use thereof for producing a polymer. The invention also relates to the polymer obtained by polymerising said monomer, and to the use thereof in a composition for producing coatings.
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Paragraph 0280-0283
(2021/06/22)
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- Organocatalytic Synthesis of Substituted Vinylene Carbonates
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The organocatalytic synthesis of substituted vinylene carbonates from benzoins and acyloins was studied using diphenyl carbonate as a carbonyl source. A range of N-Heterocyclic Carbene (NHC) precursors were screened and it was found that imidazolium salts were the most active for this transformation. The reaction occurs at 90 °C under solvent-free conditions. A wide range of substituted vinylene carbonates (symmetrical and unsymmetrical, aromatic or aliphatic), including some derived from natural products, were prepared with 20–99% isolated yields (24 examples). The reaction was also developed using thermomorphic polyethylene-supported organocatalysts as recoverable and recyclable species. The use of such species facilitates the workup and allows the synthesis of vinylene carbonates on the preparative scale (>30 g after 5 runs). (Figure presented.).
- Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas
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supporting information
p. 5129 - 5137
(2021/09/18)
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- Method for preparing 4,5-dimethyl-1,3-dioxol-2-one
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The invention provides a method for preparing 4,5-dimethyl-1,3-dioxol-2-one by using diphenyl carbonate as a high-activity green carbonyl source, which comprises the following steps: adding 2,3-butanediol and diphenyl carbonate as raw materials into an organic solvent, and carrying out heat preservation and stirring reaction under the action of a catalyst; and carrying out reduced pressure distillation on an obtained reaction solution to remove a solvent, further conducting recrystallizing to obtain high-purity 4,5-dimethyl-1,3-dioxol-2-one, washing the recrystallized mother solution by using alkali liquor, conducting separating to obtain a water phase, and then adjusting the pH value of the water phase to 5-7 to recover phenol. Through the process technology, the method has the advantages of simplified production process, mild reaction conditions, high product purity, safety, environmental protection and low production cost, and diphenyl carbonate can be regenerated through a byproduct phenol.
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Paragraph 0023-0026
(2021/07/24)
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- Preparation method of olmesartan medoxomil key intermediate
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The invention discloses a preparation method of an olmesartan medoxomil key intermediate, and belongs to the technical field of medicine synthesis. The key points of the technical scheme are as follows: triphosgene with relatively low toxicity is adopted to replace gaseous phosgene, so that the problems of storage and transportation are solved; and a molecular distillation technology is utilized to treat the crude product, so that the occurrence of a polymer at high temperature is avoided, and a high-yield product is obtained.
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Paragraph 0013-0016
(2021/08/07)
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- Method for synthesizing 4, 5-dimethyl-1, 3-dioxole-2-one
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The invention discloses a method for synthesizing 4, 5-dimethyl-1, 3-dioxole-2-one, which comprises the following steps: step 1, cyclizing 2, 3-butanedione and triphosgene to obtain 4, 5-dichloro-4, 5-dimethyl-1, 3-dioxole-2-one, and carrying out dechlorination on the 4, 5-dichloro-4, 5-dimethyl-1, 3-dioxole-2-one under the action of a reduction reagent to prepare 4, 5-dimethyl-1, 3-dioxole-2-one.The method is mild in condition, simple and efficient.
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Paragraph 0020-0023
(2020/05/01)
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- Preparation method for 4-chloromethyl-5-methyl-1,3-dioxol-2-one
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The invention specifically relates to a preparation method for 4-chloromethyl-5-methyl-1,3-dioxol-2-one, belonging to the technical field of chemical synthesis. According to the invention, acetoin isused as a raw material and reacts with chloroformate in a solvent under the action of a catalyst so as to produce DMDO; the prepared DMDO is further reacts with a chlorinating reagent and a free radical initiator in a solvent to obtain a crude DMDO-Cl product; and then rectification is carried out so as to obtain a fine DMDO-Cl product. The fine DMDO-Cl product has a purity of 99% or above.
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Paragraph 0017; 0021
(2018/04/21)
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- By using the carbon dioxide preparation 4, 5 - dimethyl - 1, 3 - dioxo heterocyclic pentene - 2 - one method
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The invention discloses a method for preparing 4,5-dimethyl-1,3-dioxole-2-ketone by using carbon dioxide. The method comprises the steps as follows: 3-hydroxy-2-butanone is isomerized into an enol structure; under the condition of alkaline esterification catalysis, the enol structure and the non-toxic, non-corrosive and low-cost carbon dioxide are synthesized with a one-step method, so that an annular carbonic ester compound is formed; a 4,5-dimethyl-1,3-dioxole-2-ketone crude product is prepared through the steps of washing, crystallization, and filtering or centrifugation; and the crude product is recrystallized for purification further, so that a 4,5-dimethyl-1,3-dioxole-2-ketone product is obtained. The method accords with an atom economy reaction, greatly reduces generation and discharge of three wastes of by-products such as hydrochloric acid and the like, and is an environment-friendly and safe production process.
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Paragraph 0021-0023; 0025; 0027; 0029-0031; 0046-0049; 0057
(2017/08/25)
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- A convenient and safe synthesis of 4,5-disubstituted-2-oxo-1,3-dioxolenes
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Employing bis(trichloromethyl)carbonate (BTC), a safe and crystalline substitute of phosgene, 4,5-disubstituted-2-oxo-1,3-dioxolenes 3 have been synthesized by cyclocarbonylation of α-hydroxyketones 1 in 47-67% yield.
- Sahu, Devi Prasad
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p. 1722 - 1723
(2007/10/03)
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- Biphenyl-substituted quinoline derivatives
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Compounds of the formula wherein X, R1, R2, R3, R4, R5, R6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
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- Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
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Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been esterified through the carboxy group of sulbactam (penicillanic acid 1,1-dioxide), are useful as antibacterial agents. Certain novel compounds, which are useful as intermediates to the aforesaid antibacterial agents, are also disclosed.
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- 2-Oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide
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Certain novel 2-oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide (sulbactam) hydrolyze readily in vivo to liberate the corresponding free acid. The novel esters of this invention are useful therefore as antibacterial agents and beta-lactamase inhibitors.
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- Process for making alkylene carbonates
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A lower alkyl trichloroacetate and a vicinal alkylene diol react when heated together in the presence of a weak base to produce chloroform, a lower alkanol, and the cyclic alkylene carbonate. The chloroform and lower alkanol distill from the reaction mixture substantially as formed and the alkylene carbonate is readily separable from the residual mixture.
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