37830-90-3Relevant articles and documents
Organocatalytic Synthesis of Substituted Vinylene Carbonates
Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas
supporting information, p. 5129 - 5137 (2021/09/18)
The organocatalytic synthesis of substituted vinylene carbonates from benzoins and acyloins was studied using diphenyl carbonate as a carbonyl source. A range of N-Heterocyclic Carbene (NHC) precursors were screened and it was found that imidazolium salts were the most active for this transformation. The reaction occurs at 90 °C under solvent-free conditions. A wide range of substituted vinylene carbonates (symmetrical and unsymmetrical, aromatic or aliphatic), including some derived from natural products, were prepared with 20–99% isolated yields (24 examples). The reaction was also developed using thermomorphic polyethylene-supported organocatalysts as recoverable and recyclable species. The use of such species facilitates the workup and allows the synthesis of vinylene carbonates on the preparative scale (>30 g after 5 runs). (Figure presented.).
Preparation method of olmesartan medoxomil key intermediate
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Paragraph 0013-0016, (2021/08/07)
The invention discloses a preparation method of an olmesartan medoxomil key intermediate, and belongs to the technical field of medicine synthesis. The key points of the technical scheme are as follows: triphosgene with relatively low toxicity is adopted to replace gaseous phosgene, so that the problems of storage and transportation are solved; and a molecular distillation technology is utilized to treat the crude product, so that the occurrence of a polymer at high temperature is avoided, and a high-yield product is obtained.
Method for synthesizing 4, 5-dimethyl-1, 3-dioxole-2-one
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Paragraph 0020-0023, (2020/05/01)
The invention discloses a method for synthesizing 4, 5-dimethyl-1, 3-dioxole-2-one, which comprises the following steps: step 1, cyclizing 2, 3-butanedione and triphosgene to obtain 4, 5-dichloro-4, 5-dimethyl-1, 3-dioxole-2-one, and carrying out dechlorination on the 4, 5-dichloro-4, 5-dimethyl-1, 3-dioxole-2-one under the action of a reduction reagent to prepare 4, 5-dimethyl-1, 3-dioxole-2-one.The method is mild in condition, simple and efficient.