379229-01-3Relevant articles and documents
HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
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Paragraph 00334; 00335, (2016/01/25)
Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.
Monocyclic, substituted imidazoles as glycosidase inhibitors
Magdolen, Peter,Vasella, Andrea
, p. 2454 - 2469 (2007/10/03)
A range of 4-monosubstituted and 2,4-disubstituted 1H-imidazoles and 1H-imidazole-1-ethanols (R-C(4): CH2CH2Ph, CHOHCH 2Ph, Ph, or Me; R-C(2): CH2OH, CHOHCH2OH, CN, or CH2NHAc) were prepare
Quinazoline derivatives
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, (2008/06/13)
The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.