- KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE
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Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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Paragraph 0581; 0582
(2016/09/26)
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- 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER
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The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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- Flow-vacuum pyrolysis of polycyclic compounds. 251. Pyrolysis of some 3-mercapto-5-substituted-1,2,4-triazoles
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The flow-vacuum pyrolysis (FVP) of the 3-mercapto-5-substituted-1,2,4- triazoles 5a-c, between 475°C - 750°C, at 2 mm Hg, in inert atmosphere (4mL/min argon flow rate) and quartz pyrolysis tube (60 cm length, 1 cm internal diameter, quartz chips filling 30 mm long) afforded a complex mixture with cyano-diphenyl-sulphones 12a-c and corresponding diphenylsulphones 13a-c as main products. The reaction products were identified by GC/MS. A radical mechanism is suggested in order to explain the formation of the main reaction products.
- Istrati, Daniela,Popescu, Angela,Mihaiescu, Dan,Saramet, Ioana,Bala?u, Mihaela C.
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scheme or table
p. 497 - 503
(2009/05/11)
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- KINETICS AND MECHANISM OF THE REACTION OF CARBOXYLIC ACIDS WITH THIONYL CHLORIDE IN THE PRESENCE OF DIMETHYLFORMAMIDE
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A study was carried out on the reaction of carboxylic acids with thionyl chloride in the presence of dimethylformamide.Correlation analysis of a reaction series of substituted benzoic acids with thionyl chloride indicated that this reaction is electrophilic in nature.The ionic complex of dimethylformamide and thionyl chloride reacts rapidly with the carboxylic acid to release hydrogen chloride and form the chloride of the mixed anhydride of thiodimethyliminium and the carboxylic acid, which undergoes rearrangement in the rate-limiting step to regenerate the catalyst and liberate the acid chloride and sulfur dioxide.
- Vulakh, E. L.,Ivanova, V. M.,Nemleva, S. A.
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p. 620 - 627
(2007/10/02)
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