- Compounds for and methods of treating diseases
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The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).
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- AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
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Page/Page column 57
(2010/04/25)
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- Inhibitors of microsomal triglyceride transfer protein and method
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Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure STR1 wherein R1 to R7, Q, X and Y are as defined herein.
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- Nucleic acids encoding microsomal trigyceride transfer protein
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Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
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- SUBSTITUTED 1H-IMIDAZOLES
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Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These compounds have the general formula STR1 wherein n=1 or 2,R 1, R. sub.2, R 3 and R 4 =hydrogen, halogen, hydroxyl C 1-C 4 alkyl or C 1-C 4 alkoxy,R 5 = hydrogen of C 1-C 4 alkyl with the proviso that R 1, R. sub.2, R 3, R. sub.4 and R 5, cannot simultaneously be hydrogen when n is equal to 2. These new compounds exhibit anti-ischemic and anti-hypertensive activities.
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- Synthesis of 6,16,22,32-tetrahydroxy[3.3.3.3]metacyclophane with the aid of a new copper catalyst
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Metacyclophane 2 has been prepared in 4 steps starting from 2- bromoanisole with the aid of a new copper catalyst. The catalyst was prepared by mixing CuBr-SMe2 with LiSPh and LiBr in THF.
- Burns, Dennis H.,Miller, Jeffrey D.
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p. 5189 - 5192
(2007/10/02)
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