38011-77-7Relevant articles and documents
Compounds for and methods of treating diseases
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, (2021/10/27)
The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).
Inhibitors of microsomal triglyceride transfer protein and method
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, (2008/06/13)
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure STR1 wherein R1 to R7, Q, X and Y are as defined herein.
SUBSTITUTED 1H-IMIDAZOLES
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, (2008/06/13)
Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These compounds have the general formula STR1 wherein n=1 or 2,R 1, R. sub.2, R 3 and R 4 =hydrogen, halogen, hydroxyl C 1-C 4 alkyl or C 1-C 4 alkoxy,R 5 = hydrogen of C 1-C 4 alkyl with the proviso that R 1, R. sub.2, R 3, R. sub.4 and R 5, cannot simultaneously be hydrogen when n is equal to 2. These new compounds exhibit anti-ischemic and anti-hypertensive activities.