380389-67-3Relevant articles and documents
A catalytic intramolecular nitrene insertion into a copper(i)-N-heterocyclic carbene bond yielding fused nitrogen heterocycles
Fauché, Kévin,Nauton, Lionel,Jouffret, Laurent,Cisnetti, Federico,Gautier, Arnaud
, p. 2402 - 2405 (2017/02/23)
N-(2-Azidophenyl)azolium salts were easily prepared and reacted with copper(i) under conditions allowing the formation of NHC complexes. Under these conditions, the formation of benzimidazo-fused heterocycles occurred under catalytic, efficient and very mild conditions. This reaction is proposed to proceed via dinitrogen elimination and imido/nitrene-NHC cyclization.
New imidazolo-heteroaryl derivatives with antibacterial properties
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, (2008/12/08)
The invention relates to Imidazolo-heteroaryl derivatives of formula (I) The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro.
N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES
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Page/Page column 186-187, (2008/06/13)
The present invention relates to heterocyclic substituted N-Oxides of formula (I), the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
HETEROCYCLIC SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 186-187, (2008/06/13)
The present invention relates to heterocyclic substituted bisarylurea derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
Synthesis and properties of 4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine derivatives
Ivanov, Vladimir V.,Yurchenko, Alexandr A.,Chernega, Alexander N.,Pinchuk, Alexandr M.,Tolmachev, Andrej A.
, p. 84 - 92 (2007/10/03)
A number of 4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine derivatives were prepared by the direct phosphorylation of 1-(4-Chloro-phenylcarboxamido)-2-(1H-1-imidazolyl)-5-trifluoromethylbenzene in basic medium with phosphorus(III) bromide and dibromophenylphosphine. The amide was reacted with phosphorus(III) bromide to yield the tricyclic compound. The tricyclic compound with a trivalent phosphorus atom went through the diazaphosphine ring opening upon treatment with secondary amines in the presence of sulphur.