38062-72-5

Basic information

• Product Name: H-LEU-HIS-OH
• Synonyms: L-LEUCYL-L-HISTIDINE;H-LEU-HIS-OH;Leu-His-OH;L-Leu-L-His-OH;Nα-L-Leucyl-L-histidine
• CAS NO: 38062-72-5
• Molecular Formula: C12H20N4O3
• Molecular Weight: 268.31
• Mol File: 38062-72-5.mol

Chemical Properties

• Boiling Point: 603.9°C at 760 mmHg
• Flash Point: 319°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 1.97E-15mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: -15°C
• PKA: 2.87±0.10(Predicted)
• CAS DataBase Reference: H-LEU-HIS-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-LEU-HIS-OH(38062-72-5)
• EPA Substance Registry System: H-LEU-HIS-OH(38062-72-5)

Safety Data

• Hazardous Substances Data: 38062-72-5(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
H-LEU-HIS-OH is used as a research tool for studying the effects of specific amino acid sequences on protein conformation and function. Its unique structure allows scientists to investigate the interactions between amino acids and their influence on protein stability and activity.
Used in Pharmaceutical Development:
In the pharmaceutical industry, H-LEU-HIS-OH is utilized as a potential therapeutic agent, given its capacity to modulate protein structures, which could have implications for the treatment of various diseases where protein misfolding or malfunction is a factor.
Used in Biotechnology:
H-LEU-HIS-OH is employed as a component in the development of novel biotechnological products, such as engineered proteins with enhanced or altered functions, which could be applied in areas like biocatalysis, diagnostics, or therapeutics.
Used in Peptide Synthesis:
H-LEU-HIS-OH serves as a building block in the synthesis of larger peptides or peptide-based drugs, where its specific properties may contribute to the overall efficacy and stability of the final product.
Used in Nutritional Supplements:
Given its constituent amino acids, H-LEU-HIS-OH may be used in nutritional supplements to support muscle growth and recovery, as well as to maintain a balanced amino acid profile in the body.
Each application of H-LEU-HIS-OH leverages its distinct chemical and biological properties, highlighting its versatility and potential across multiple disciplines.

InChI:InChI=1/C12H20N4O3/c1-7(2)3-9(13)11(17)16-10(12(18)19)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

Upstream product

• 28659-88-3 2-bromo-4-methylpentanoyl chloride 
• 1499-46-3 L-Histidine methyl ester 
• 910890-97-0 N^α-((Ξ)-2-bromo-4-methyl-valeryl)-L-histidine-methyl ester 
• 880258-24-2 N^α-((Ξ)-2-bromo-4-methyl-valeryl)-L-histidine 

Relevant articles and documents

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.