381230-33-7

Basic information

• Product Name: 3-(3,4-DIMETHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 3-(3,4-DIMETHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE;AKOS BBS-00001245
• CAS NO: 381230-33-7
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.33
• Mol File: 381230-33-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3,4-DIMETHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(381230-33-7)
• EPA Substance Registry System: 3-(3,4-DIMETHOXY-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(381230-33-7)

Safety Data

• Hazardous Substances Data: 381230-33-7(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 100-63-0 phenylhydrazine 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 58697-62-4 N-[1-(3,4-dimethoxy-phenyl)-ethylidene]-N'-phenyl-hydrazine 

Relevant articles and documents

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Solubility and solution thermodynamics of novel pyrazolo chalcone derivatives in various solvents from 298.15?K to 328.15?K

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Abstract: A series of new Schiff bases were synthesized by microwave assisted reactions of substituted 1-phenyl-1H-pyrazole-4-carbaldehyde and 2-aminophenol in ethanol and characterized by elemental analysis and spectroscopic (IR, 1H NMR and MS) data. The crystal structures of four compounds were studied using single-crystal XRD data. Molecular docking studies of all synthesized compounds were performed into the binding site of a protein 3GCW to gain comprehensive understanding into possible binding modes. These compounds were also screened for anticancer activity against the liver (HEP-G2) cell line using the sulphorhodamine-B assay method. Adriamycin i.e. doxorubicin was used as reference standard. One of the compounds shows anticancer activity close to the famous anticancer agent doxorubicin, which was used as control in this study. It is observed that all molecules show activity close to the standard in high concentrations only. Graphical Abstract: Present study describes the anticancer activity and crystal structure study of Schiff bases of substituted pyrazole-4-carbaldehyde with 2-aminophenol. Docking study of all compounds against human hepatoma cell line, HEP-G2 correlates with in vitro activity. [Figure not available: see fulltext.].