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Phenylhydrazine
Cas No: 100-63-0
USD $ 2.0-2.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Phenylhydrazine
Cas No: 100-63-0
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Phenylhydrazine
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phenyl hydrazine
Cas No: 100-63-0
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Phenylhydrazine
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USD $ 25.0-40.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Phenylhydrazine CAS 100-63-0
Cas No: 100-63-0
No Data 200 Kilogram 1000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
CHemwill -- Phenylhydrazine
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USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
High quality Phenylhydrazine supplier in China
Cas No: 100-63-0
No Data No Data No Data Simagchem Corporation Contact Supplier
100-63-0 C6H8N2 Phenylhydrazine
Cas No: 100-63-0
No Data 5 Gram 1 Kilogram/Day HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier

100-63-0 Usage

Acute toxicity

oral-rat LD50: 188 mg/kg; Oral-Mouse LD50: 175 mg/kg

Storage characteristics

Treasury: ventilation, low-temperature and dry; store it separately from oxidants, acids and food additives

Extinguishing agent

water, spray, foam, CO2, sand

Definition

ChEBI: A phenylhydrazine that is the monophenyl derivative of hydrazine.

Purification Methods

Purify phenylhydrazine by chromatography, then crystallise it from pet ether (b 60-80o)/*benzene. Store it in the dark under N2 as it turns yellow, then red, on exposure to air. It is best stored as the hydrochloride salt; see below. [Coleman Org Synth Coll Vol I 442 1941, Shaw & Stratton J Chem Soc 5004 1962, Beilstein 15 IV 50.]

Production method

It can be produced from aniline which undergoes diazotization, reduction, acid precipitation to obtain phenylhydrazine hydrochloride and then further neutralization to obtain phenylhydrazine.
The preparation method is based on aniline which successively undergoes diazotization, reduction, acid precipitation, and neutralization to derive it.
Diazotization: add a certain amount of water, 30% hydrochloric acid and aniline to the reaction pot, cooled to 2 ℃, control the temperature at around 0~5 ℃ and add drop wise of solution of sodium nitrite to until the starch iodide test solution turns blue, stir for 30 mins for completion of the reaction and obtain the diazonium solution.
Reduction: add water, sodium bisulfite and 30% alkaline solution to the reduction kettle, heated to 80 ℃, maintain the temperature in 80~85 ℃ and pH = 6.2~6.7, within 20min trickle add the above diazo solution, stirring was continued for 1.5 h, then add zinc powder, diatomaceous earth, stirred filtrate with the filtrate suck into the acid precipitation tank.
Acid precipitation: to the above filtrate add 30% hydrochloric for acid precipitation at 70 ℃, the temperature is maintained in 85~90 ℃, stir for 10min and cool to below 20 ℃, suck, filtration to yield phenylhydrazine hydrochloride.
Neutralization: add the alkaline solution to the reaction pot, stir and simultaneously add the above phenylhydrazine hydrochloride and an appropriate amount of water, heated to 50 ℃, stirred at 50~60 ℃ for 1 h, allowed to stand for more than 8h, separate out the lower aqueous solution, It was the top oil that was phenylhydrazine with the content of about 80% and the total yield of 83.5%.

Hydrazine derivative

Phenylhydrazine is also known as the hydrazinobenzene. It was first successfully synthesized by the German organic chemist Hermann-Emil-Fischer in 1875 and is the first synthesized hydrazine derivatives. At room temperature, it is a pale yellow crystalline or oily liquid while at low temperature it appears as monoclinic prismatic crystals. It can be easily subject to oxidization in the air and exhibit dark brown or dark red. It is one of the hydrazine derivatives and is often abbreviated as PhNHNH2. It is slightly soluble in water and alkali solution and can be dissolved in dilute acid. It is miscible with ethanol, ethyl ether, chloroform and benzene. Common method of its preparation is through the reaction between aniline and sodium nitrite under the action of hydrochloric acid for generation of diazonium salt which is then reduced by sulfite/sodium reduction for obtaining it. Acid precipitation can generate phenylhydrazine hydrochloride with neutralization generating phenylhydrazine. It can be applied to making dyes, drugs, and being used as developer. It is also an important reagent for identification of carbonyl group and can be used for identifying aldehydes, ketones and carbohydrates. It can react with benzaldehyde to generate phenylhydrazine. We can use the hydrazone generated through phenylhydrazine or 2, 4-dinitrophenylhydrazine to identify aldehydes and ketones, It can trigger Fischer indole synthesis upon reaction with aldehydes and ketones (first found by the Emil Hermann Fischer in 1883, the reaction is using phenylhydrazine and aldehyde, ketone for heating and rearrangement under acid-catalysis for the elimination of one molecule of ammonia to give 2-or 3-substituted indole.) to give indole ring-class compound.

Phenylhydrazine: preparation and application

Phenylhydrazine is the first synthetic hydrazine derivatives which can often be used as intermediates of organic dyes, pharmaceuticals and pesticide. It can also be used as organic intermediates for synthesis of pyrazoline, triazole, and indole; It can also be used as dye intermediates like disazo dye intermediates such as 1-phenyl-3-methyl-5-pyrazolone and so on; It can also be used as pharmaceutical intermediates for preparation of antipyretic, analgesic, anti-inflammatory drugs such as antipyrine and aminopyrine, etc; it can also be used as photography drugs (photosensitive dye); phenylhydrazine is also the raw material for the production of pesticides "imputed phosphorus"; phenylhydrazine is also an important kind of carbonyl group identification reagents used for identifying aldehydes, ketones and carbohydrates.
Phenylhydrazine is toxic. After inhalation, due to hemolysis, it can cause anemia and headache and can even cause jaundice in severe cases. It can also have stimulating effect on the eyes such as causing corneal disorders. Rat-oral LD50:188 mg/kg. Workplace: maximum allowable concentration: 0.44mg/m3.
Lab often uses aniline as raw materials for reaction with sodium nitrite in hydrochloric acid for generating diazonium salt and then reacted with sulfur dioxide and sulfurous acid for reduction to produce phenylhydrazine sodium sulfonate and further salting via hydrochloric acid to form phenylhydrazine hydrochloride. After neutralization and deacidification, we can obtain phenylhydrazine.
Reaction formula

Chemical Properties

Phenylhydrazine is pale yellow oily liquid with the melting point being 19.8 ℃ and boiling point being 173.5 ℃/13.33kPa, n20D being 1.608 and the relative density being 1.0978 (20 ℃). It is slightly soluble in water and petroleum ether and soluble in alcohol, ether, chloroform and benzene. It can be evaporated together with steam. It is also easily to get dark in the air. Phenylhydrazine hydrochloride [59-88-1] is solid with the m.p. being 250~254 ℃ (decomposition).

Air & Water Reactions

When exposed to air becomes red-brown. Slightly denser than water and slightly soluble in water.

Chemical Properties

colourless to pale yellow liquid

Uses

In the field of pesticide production, phenylhydrazine can be used for synthesizing the intermediate 1-phenyl-semicarbazide of the organophosphorus pesticides, triazophos as well as the intermediate 1-phenyl-3, 6-hydroxy pyridazine of pyridaphenthione. It is also the intermediates of the novel bactericidal varieties, famoxadone and fenamidone. In addition, hydrazine benzene, as a raw material for organic synthesis, can also be used as the intermediates of dye and pharmaceutical industry as well as being used as an analytical reagent.
The product is the intermediate of dye, pharmaceuticals and pesticides. It can be used for the production of Naphthol AS-G, drugs such as antipyrine and so on. Dissolving the phenylhydrazine in 95% ethanol and following by addition of benzaldehyde and reflux for 1 h can obtain the phenylhydrazone. Phenylhydrazone can also be used as the intermediate of organic synthesis. Phenylhydrazine is also used as an analytical reagent.
As a weak base, it can be used to precipitate lead, chromium and other trivalent, tetravalent element in the form of hydroxide. It can also be used for photometric determination of aluminum, chromium, copper, molybdenum, titanium, and zirconium. It can also be used for verification of gold, iridium, molybdenum, palladium, platinum, and silver. It can be used as the reducing agent for colorimetric assay of phosphorus acid. It can also react with aldehydes, ketones and sugars to get phenylhydrazone with different melting points according which we will be able to identify these substances.

Health Hazard

Material is corrosive to tissue. Exposure can cause vomiting, diarrhea, fatigue, headache, and irritation and itchiness of the eyes and skin.

Flammable and hazard characteristics

it is combustible upon fire with heating emitting toxic nitrogen compound gas

Reactivity Profile

Phenylhydrazine may ignite spontaneously when in contact with oxidants such as hydrogen peroxide or nitric acid, oxides of iron or copper, or manganese, lead, copper or their alloys. Will not polymerize [USCG, 1999].

Uses

An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.

General Description

Pale yellow crystals. Melting point 66°F. Becomes an oily liquid. Toxic by ingestion, inhalation and skin absorption. Flash point 192°F. Autoignition temperature 345°F. Soluble in alcohol.

Toxicity grading

highly toxic

Hermann-Emil-Fischer

Fischer is a German organic chemist. He used phenylhydrazine to react with carbohydrate and generate hydrazone and osazone and form a crystalline compound which is easy for purification. Then it is decomposed into pure sugar. This is a powerful means for studying carbohydrate structures and synthesis of a variety of sugars and enables the theoretic clarification of the structure of glucose and summarizing of the general stereoisomerism phenomenon of saccharides and further using of Fischer projection for describing it. He has also demonstrated that the caffeine, theophylline, uric acid all belongs to purine derivatives and also had successfully synthesized purine. He also had opened up the study of proteins and had demonstrated that amino acids forms polypeptide via peptide bond and successfully synthesized polypeptides. In 1902, Fischer, because of the synthesis of purine and carbohydrate, was awarded for the Nobel Prize in Chemistry.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Professional Standards

TLV-TWA 0.1 PPM; TWA 5 PPM (22 mg/cubic meter); STEL 2 mg/m3

Category

toxic substances
InChI:InChI=1/C6H5.H3N2/c1-2-4-6-5-3-1;1-2/h1-6H;1-2H2

100-63-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (P26252)  Phenylhydrazine  97% 100-63-0 P26252-500G 649.35CNY Detail
Aldrich (P26252)  Phenylhydrazine  97% 100-63-0 P26252-100G 278.46CNY Detail
Aldrich (P26252)  Phenylhydrazine  97% 100-63-0 P26252-5G 267.93CNY Detail
Alfa Aesar (A11246)  Phenylhydrazine, 97%    100-63-0 1000g 971.0CNY Detail
Alfa Aesar (A11246)  Phenylhydrazine, 97%    100-63-0 250g 313.0CNY Detail
Alfa Aesar (A11246)  Phenylhydrazine, 97%    100-63-0 50g 148.0CNY Detail

100-63-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name phenylhydrazine

1.2 Other means of identification

Product number -
Other names Fenilidrazina [Italian]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-63-0 SDS

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Based on the theoretical and REMPI spectroscopic study, a comparison between 1-methylphenylhydrazine and phenylhydrazine in the excited S1 state is conducted to reveal the formation and influence of p–p–π conjugation. The ab initio and DFT calculations predict that phenylhydrazine and 1-methy...detailed

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