381709-65-5

Basic information

• Product Name: ethyl 5-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
• Synonyms: ethyl 5-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
• CAS NO: 381709-65-5
• Molecular Formula: C21H22N2O3
• Molecular Weight: 350.41098
• Mol File: 381709-65-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate(381709-65-5)
• EPA Substance Registry System: ethyl 5-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-2-methyl-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate(381709-65-5)

Safety Data

• Hazardous Substances Data: 381709-65-5(Hazardous Substances Data)

Upstream product

• 65713-63-5 ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate 
• 83-18-1 2,5-dimethyl-1-phenyl-1H-pyrrole-3-carbaldehyde 
• 626-34-6 ethyl aminocrotonate 
• 78120-39-5 (E)-ethyl 3-amino-2-(2-chloroacetyl)but-2-enoate 

Relevant articles and documents

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.