626-34-6Relevant articles and documents
Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method
Hosseininasab, Fatemeh Sadat,Memarian, Hamid Reza
, (2022/01/11)
Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared β-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.
Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp2)-H Alkynylation of Acceptor-Substituted Enamines
Han, Chunyu,Tian, Xianhai,Zhang, Huili,Rominger, Frank,Hashmi, A. Stephen K.
supporting information, p. 4764 - 4768 (2021/06/30)
A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.
Chiral diphosphine ligand rhodium complex containing tetra (3, 5-bis (trifluoromethylphenyl) boron anions and preparation method and application thereof
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Paragraph 0056-0065, (2021/10/27)
The invention relates to a chiral diphosphine ligand rhodium complex containing tetra (3, 5-bis (trifluoromethylphenyl) boron anions and a preparation method and application thereof. Specifically, the high-stability chiral diphosphine ligand rhodium complex containing BArF anions can be obtained by complexing a chiral diphosphine ligand with a rhodium salt and then carrying out anion exchange with NaBArF. The complex can efficiently catalyze an asymmetric catalytic hydrogenation reaction of beta-dehydroamino acid ester to prepare a beta-amino acid ester derivative with high optical purity, so that a synthetic method suitable for industrialization is provided for optically pure beta-amino acid and beta-amino alcohol, and the complex has a good application prospect.