cas 38175-34-7, 4-(3'-Methoxyphenyl)-2-pyrrolidinone | Articles data ｜lookchem

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38175-34-7

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Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket
A series of 3-(3-hydroxyphenyl)pyrrolidine analogues which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality have been synthesized and their in vitro binding affinities at human dopamine receptors have been evaluated. Our ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D3 receptor. The N-alkyl analogues constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D3 receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogues were also prepared in order to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogues were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.
Omran, Anahid,Eslamimehr, Shakiba,Crider, A. Michael,Neumann, William L.
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p. 1897 - 1902
(2018/04/10)

GSK-3BETA INHIBITOR
For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.
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Page/Page column 27

(2011/04/13)

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1056971-34-6
N-benzyl-3-(3-methoxyphenyl)pyrrolidine

Chemical Properties

Boiling Point: 395.105 °C at 760 mmHg
Flash Point:192.753 °C
Density: 1.129 g/cm³
PSA: 38.33000
LogP: 1.62750

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