38175-34-7

Usage

Uses

Used in Organic Synthesis:
4-(3'-Methoxyphenyl)-2-pyrrolidinone is used as a versatile intermediate for the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique chemical structure allows for the creation of a wide range of compounds with diverse applications in the chemical and pharmaceutical industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-(3'-Methoxyphenyl)-2-pyrrolidinone is utilized as a key building block for the development of new drug compounds and pharmacological agents. Its potential pharmaceutical and therapeutic applications make it an important component in the discovery and design of novel medications.
Used in Drug Development:
4-(3'-Methoxyphenyl)-2-pyrrolidinone is employed in drug development as a precursor for the synthesis of compounds with potential therapeutic effects. Its unique reactivity and chemical properties contribute to the creation of innovative drugs that address various medical conditions and improve patient outcomes.

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 372944-87-1 methyl 3-(3-methoxyphenyl)-4-nitrobutanoate 
• 38693-90-2 trans-3-(3-methoxyphenyl)acrylic acid methyl ester 

Downstream Products

• 1056971-34-6 N-benzyl-3-(3-methoxyphenyl)pyrrolidine 
• 38175-35-8 3-(3-methoxyphenyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket

A series of 3-(3-hydroxyphenyl)pyrrolidine analogues which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality have been synthesized and their in vitro binding affinities at human dopamine receptors have been evaluated. Our ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D3 receptor. The N-alkyl analogues constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D3 receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogues were also prepared in order to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogues were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.