- Doxepin analogs and methods of use thereof
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The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof.
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Page/Page column 51
(2008/06/13)
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- Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
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Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula STR1 wherein m is 0 to 3, n is 1 to 5, Y1 and Y2 are H or halogen, R2, R3 and R4 are H, metal ion, C1 to C8 alkyl, C3 to C12 alkenyl, or prodrug ester, and R1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.
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- Modification of Photochemical Reactivity by Cyclodextrin Complexation: Product Selectivity in Photo-Fries Rearrangement
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Cyclodextrin encapsulation, both in the solid state and in aqueous solution brings about a remarkable regulation of the photo-Fries rearrangement of phenyl esters and anilides.In comparison to the non-selective mixture of ortho and para-rearranged isomers along with the deacylated product obtained in organic solvents, the solid β-cyclodextrin complexes of unsubstituted esters and anilides show a remarkable 'ortho-selectivity'.An impressive 'regio-selectivity' among the two ortho-rearranged isomers is observed for meta-substituted esters and anilides upon irradiation as β-cyclodextrin complexes.Specific orientations of the unsubstituted and meta-substituted esters and anilides in the β-cyclodextrin cavity are suggested to be responsible for the observed selectivity.
- Syamala, M. S.,Rao, B. Nageswer,Ramamurthy, V.
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p. 7234 - 7242
(2007/10/02)
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