- Thiophene compounds and applications of thiophene compounds serving as USP7 inhibitors and antitumor drugs
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The invention discloses compounds shown in the formula I or nitrogen oxides, pharmaceutically acceptable salt or solvate of the compounds, a preparation method of the compounds, and applications of the compounds in pharmacy, and particularly provides the applications of the compounds serving as USP7 inhibitors and antitumor drugs. Pharmacodynamic experiment results show that the compounds in the formula I have inhibition effects on a USP7 enzyme and also have proliferation inhibition effects on human colon cancer cells HCT-116. Therefore, the compounds can be used for preparing the drugs for preventing or treating diseases related to tumors. The formula I is shown in the description.
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Paragraph 0047; 0049; 0050
(2019/01/16)
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- Ring fluorinated thiophenes: Applications to liquid crystal synthesis
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Ring fluorinated thiophenes were synthesized via a Balz-Schiemann fluorination approach and were successfully employed in the synthesis of liquid crystals using regioselective electrophilic bromination and regioselective Suzuki coupling chemistry.
- Kiryanov, Andre A.,Seed, Alexander J.,Sampson, Paul
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p. 8797 - 8800
(2007/10/03)
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