- Anti-infective agents
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Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
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- Anti-infective agents
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Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
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- Anti-infective agents
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The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC
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Page/Page column 97
(2010/02/08)
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- 3-thiazolylthio carbacephem antibacterial agents
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The present invention provides compounds of the formula STR1 wherein R is hydrogen, C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6 alkynyl, C3 -C6 cycloalkyl, or C1 -C6 haloalkyl; A and A' are independently hydrogen, C1 -C6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2 or 3 hetero atoms selected from nitrogen or sulfur, C1 -C6 alkoxy, or phenyl; or A and A' taken together form a group of the formulae STR2 wherein X is hydrogen, halo, C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods of treatment using the above compounds.
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- 3-NITRO-2-PYRIDINESULFENYL GROUP FOR PROTECTION AND ACTIVATION OF THE THIOL FUNCTION OF CYSTEINE
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The use of the 3-nitro-2-pyridinesulfenyl (Npys) halide, a versatile reagent in peptide chemistry, for the protection and activation of the thiol function is reported.Boc-Cys(Npys)-OH is prepared starting from bis(N-t-butyloxycarbonyl)-L-cystine.The Npys group is easily removed by treatment with a stoichiometric amount of tri-n-butylphosphine in the presence of water, but it is resistant to acids such as trifluoroacetic acid, HCl, and HF.Importantly, the cysteine residue modified with the Npys group can react selectively with free thiol of cysteine to afford a cystine disulfide bond.
- Matsueda, Rei,Kimura, Takahide,Kaiser, Emil Thomas,Matsueda, Gary R.
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p. 737 - 740
(2007/10/02)
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