38240-29-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Nitro-2-pyridinethiol is utilized as a key intermediate in the synthesis of a broad spectrum of pharmaceuticals and agrochemicals. Its chemical structure allows for the development of new drugs and pesticides, contributing to advancements in healthcare and agriculture.
Used in Dye and Pigment Production:
In the dye and pigment industry, 3-Nitro-2-pyridinethiol serves as an essential intermediate. Its properties enable the creation of a variety of dyes and pigments, enhancing color options and performance in different applications, such as textiles, plastics, and printing inks.
Used in Corrosion Inhibition:
3-Nitro-2-pyridinethiol is employed as a corrosion inhibitor in various industrial applications. Its ability to prevent or reduce the corrosion of metals is valuable in protecting infrastructure and equipment, thereby extending their service life and reducing maintenance costs.
Used in Organic Electronics:
3-Nitro-2-pyridinethiol has been studied for its potential use in organic electronics. Its properties make it a candidate for components in organic electronic devices, such as organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs), where it could contribute to improved performance and efficiency.
Used in Synthesis of Metal Chelating Agents:
3-Nitro-2-pyridinethiol is also used as a building block in the synthesis of metal chelating agents. These agents are crucial in various applications, including environmental remediation, where they can bind and remove heavy metals from contaminated sites, and in the medical field for the treatment of metal poisoning.
It is crucial to handle 3-Nitro-2-pyridinethiol with care due to its toxic nature. Ingestion, inhalation, or skin absorption can lead to harmful effects, necessitating proper safety measures during its use and storage.

InChI:InChI=1/C5H4N2O2S/c8-7(9)4-2-1-3-6-5(4)10/h1-3H,(H,6,10)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 76880-29-0 N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine 

Downstream Products

• 38240-21-0 2-mercapto-3-amino pyridine 
• 94527-46-5 3-aminopyridine-2-sulfonamide 
• 676502-83-3 N-(2,4-dimethoxybenzyl)-3-[({3-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl}thio)methyl]benzamide 
• 1242435-96-6 3-nitro-2-(2-phenylsulfanyl-ethylsulfanyl)pyridine 
• 1242435-92-2 3-nitro-2-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-ethylsulfanyl]pyridine 
• 38240-21-0 3-aminopyridine-2(1H)-thione 
• 69212-32-4 2-(benzylthio)pyridin-3-amine 
• 69212-31-3 benzyl 3-nitro-2-pyridyl sulfide 
• 60781-03-5 3-Amino-5'-nitro-2,2'-dipyridyl-sulfid 

Relevant academic research and scientific papers

Anti-infective agents

Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Anti-infective agents

Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Anti-infective agents

The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC

3-thiazolylthio carbacephem antibacterial agents

The present invention provides compounds of the formula STR1 wherein R is hydrogen, C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6 alkynyl, C3 -C6 cycloalkyl, or C1 -C6 haloalkyl; A and A' are independently hydrogen, C1 -C6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2 or 3 hetero atoms selected from nitrogen or sulfur, C1 -C6 alkoxy, or phenyl; or A and A' taken together form a group of the formulae STR2 wherein X is hydrogen, halo, C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods of treatment using the above compounds.

3-NITRO-2-PYRIDINESULFENYL GROUP FOR PROTECTION AND ACTIVATION OF THE THIOL FUNCTION OF CYSTEINE

The use of the 3-nitro-2-pyridinesulfenyl (Npys) halide, a versatile reagent in peptide chemistry, for the protection and activation of the thiol function is reported.Boc-Cys(Npys)-OH is prepared starting from bis(N-t-butyloxycarbonyl)-L-cystine.The Npys group is easily removed by treatment with a stoichiometric amount of tri-n-butylphosphine in the presence of water, but it is resistant to acids such as trifluoroacetic acid, HCl, and HF.Importantly, the cysteine residue modified with the Npys group can react selectively with free thiol of cysteine to afford a cystine disulfide bond.