- PROCESS FOR PREPARING TRIENTINE DIHYDROCHLORIDE
-
The present invention relates to a process for preparing trientine dihydrochloride as an active pharmaceutical ingredient (API). The present invention relates to a process for the preparation of trientine dihydrochloride with a pharmaceutical grade of purity. The invention also relates to novel intermediates used in the preparation of trientine dihydrochloride.
- -
-
Page/Page column 13-14
(2021/10/02)
-
- A PROCESS FOR THE PREPARATION OF TRIENTINE DIHYDROCHLORIDE
-
The present invention relates to an industrially feasible and economically viable process for preparation of trientine dihydrochloride of formula (I) in significantly high yield and purity.
- -
-
-
- Synthesis method of trientine dihydrochloride
-
The invention discloses a synthesis method of trientine dihydrochloride and belongs to the field of drug synthesis. The synthesis method of trientine dihydrochloride comprises the steps: carrying outa t-butyloxycarboryl protective reaction on ethanediamine serving as an initial raw material to prepare an intermediate I; carrying out condensation on the intermediate I serving as a raw material and1, 2-dibromoethane to prepare an intermediate II; and finally, carrying out deprotection on the intermediate II serving as a raw material to synthesize trientine dihydrochloride. The synthesis methoddisclosed by the invention is short in route, low in cost, high in yield and suitable for industrialized production of trientine dihydrochloride, and the product is easy to purify.
- -
-
Paragraph 0044; 0051; 0052; 0053; 0063; 0073
(2018/07/07)
-
- IMPROVED METHOD FOR THE SYNTHESIS OF 1,2-ETHANEDIAMINE, N, N'-BIS(2-AMINOETHYL)-DIHYDROCHLORIDE(TRIENTINE DIHYDROCHLORIDE)
-
The present invention relates to an improved method for the synthesis of substantially pure 1,2-ethanediamine, N, N'-bis(2-aminoethyl)-dihydrochloride (I). Formula (I). Ν,Ν'-bis (2-aminoethyl)-l,2-ethanediamine dihydrochloride (Trientine dihydrochloride)
- -
-
Page/Page column 18; 20; 21
(2018/11/22)
-
- AN IMPROVED PROCESS FOR PREPARATION OF TRIENTINE DIHYDROCHLORIDE
-
The present invention provides a process for preparation of trientine dihydrochloride (1) comprising reaction of protected triethylene tetramine with hydrochloric acid in an aqueous system to yield the dihydrochloride salt wherein the formation of inorganic impurities and undesired salts is controlled significantly.
- -
-
Page/Page column 8
(2017/04/11)
-
- Synthesis of triethylenetetramines
-
Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
- -
-
Page/Page column 21
(2008/06/13)
-