38260-01-4

Basic information

• Product Name: TRIETHYLENETETRAMINE DIHYDROCHLORIDE
• Synonyms: syprine;triendihydrochloride;trientinehydrochloride;N,N'-bis(2-aminoethyl)ethylenediamine dihydrochloride;TRIETHYLENETETRAMIN-DIHYDROCHLORID, 2XCR IST.;TRIETHYLENETETRAMINE DIHYDROCHLORIDE, TECH.;TRIETHYLENETETRAMINE 2HCL;Triene2HCl
• CAS NO: 38260-01-4
• Molecular Formula: C₆H₁₈N₄*2ClH
• Molecular Weight: 219.16
• EINECS: 253-854-3
• Product Categories: Superoxide dismutase;Amine Salts;and Substrates;Biochemicals and Reagents;Building Blocks;Chemical Synthesis;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Nitrogen Compounds;Organic Building Blocks;R to Z;TICAR
• Mol File: 38260-01-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 120-125 °C (dec.)
• Boiling Point: 266.5 °C at 760 mmHg
• Flash Point: 143.3 °C
• Appearance: white crystalline powder
• Density: 0.958 g/cm³
• Storage Temp.: 0-6°C
• Solubility: Methanol (Slightly), Water (Slightly)
• BRN: 5961763
• CAS DataBase Reference: TRIETHYLENETETRAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYLENETETRAMINE DIHYDROCHLORIDE(38260-01-4)
• EPA Substance Registry System: TRIETHYLENETETRAMINE DIHYDROCHLORIDE(38260-01-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 2
• RTECS: KH8587085
• F: 3
• Hazardous Substances Data: 38260-01-4(Hazardous Substances Data)

Usage

Description

Trientine hydrochloride is a copper chelating agent recommended for the treatment of Wilson's Disease, especially in patients intolerant of penicillamine therapy. Unlike the latter agent, trientine is not indicated in cystinuria or rheumatoid arthritis.

Chemical Properties

white crystalline powder

Originator

Cambridge University (United Kingdom)

Uses

Different sources of media describe the Uses of 38260-01-4 differently. You can refer to the following data:
1. Triethylenetetramine Hydrochloride is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.
2. antibacterial
3. As thermosetting resin; epoxy curing agent; lubricating oil additive; analytical reagent for Cu, Ni.

Brand name

Syprine (Merck);CUPRID.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Trientine Hydrochloride is administered for relief of symptoms of Wilson′s disease for penicillamine intolerance, hence is employed as an oral medication for the treatment of an inherited defect in copper metabolism.

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Downstream Products

• 112-24-3 triethylentetramine 

Relevant articles and documents

PROCESS FOR PREPARING TRIENTINE DIHYDROCHLORIDE

The present invention relates to a process for preparing trientine dihydrochloride as an active pharmaceutical ingredient (API). The present invention relates to a process for the preparation of trientine dihydrochloride with a pharmaceutical grade of purity. The invention also relates to novel intermediates used in the preparation of trientine dihydrochloride.

IMPROVED METHOD FOR THE SYNTHESIS OF 1,2-ETHANEDIAMINE, N, N'-BIS(2-AMINOETHYL)-DIHYDROCHLORIDE(TRIENTINE DIHYDROCHLORIDE)

The present invention relates to an improved method for the synthesis of substantially pure 1,2-ethanediamine, N, N'-bis(2-aminoethyl)-dihydrochloride (I). Formula (I). Ν,Ν'-bis (2-aminoethyl)-l,2-ethanediamine dihydrochloride (Trientine dihydrochloride)

AN IMPROVED PROCESS FOR PREPARATION OF TRIENTINE DIHYDROCHLORIDE

The present invention provides a process for preparation of trientine dihydrochloride (1) comprising reaction of protected triethylene tetramine with hydrochloric acid in an aqueous system to yield the dihydrochloride salt wherein the formation of inorganic impurities and undesired salts is controlled significantly.