- Efficient synthesis of a new pyrimidine derivative
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A ready preparation for a new pyrimidine derivative, 2-aminomethyl-5-chloropyrimidine, from s-methylthiouronium sulphate and mucochloric acid is reported.
- Liang, Yong-Min,Luo, Sheng-Jun,Zhang, Zhao-Xin,Ma, Yong-Xiang
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- CYCLOALKYLAMINO ACID DERIVATIVES
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The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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Page/Page column 34
(2008/06/13)
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- General and facial synthesis of 2-amino-5-halogenpyrimidine-4-carboxylic acids and their derivatives
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A facile synthetic approach to 2-amino-5-halogen-pyrimidine-4-carboxylic acids from 5-halogen-2-methylsulfonylpyrimidine-4-carboxylic acid by nucleophilic displacement of the methylsulfonyl group with primary and secondary aliphatic amines has been develo
- Blyumin, Evgeniy V.,Neunhoeffer, Hans,Volovenko, Yulian V.
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p. 2231 - 2241
(2008/02/07)
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