- Reaction of esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate
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The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0-5°C results in the nucleophilic substitution of readily eliminating groups (Cl, CH3O, CH3S) at the position 2 of the pyrimidine r
- Tumkevicius,Yakubkene,Vainilavicius
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- FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE
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Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
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Page/Page column 91
(2008/06/13)
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- A general procedure for the synthesis of 2-substituted pyrimidine-5-carboxylic esters
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A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.
- Zhichkin, Pavel,Fairfax, David J.,Eisenbeis, Shane A.
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p. 720 - 722
(2007/10/03)
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