38275-41-1

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-(methylthio)pyrimidine-5-carboxylate is used as a key intermediate for the synthesis of pyrimidine derivatives. These derivatives are known for their diverse biological activities, including antiviral, anticancer, and anti-inflammatory properties. Methyl 2-(methylthio)pyrimidine-5-carboxylate plays a crucial role in the development of new drugs targeting various diseases.
Used in Chemical Industry:
In the chemical industry, Methyl 2-(methylthio)pyrimidine-5-carboxylate is utilized for the preparation of pyrimidines through cyclocondensation of amidinium with formylpropenolate. This process allows for the creation of a variety of pyrimidine-based compounds with potential applications in different fields, such as agrochemicals, dyes, and materials science.

InChI:InChI=1/C7H8N2O2S/c1-11-6(10)5-3-8-7(12-2)9-4-5/h3-4H,1-2H3

Upstream product

• 287714-35-6 2-chloro-pyrimidine-5-carboxylic acid methyl ester 
• 5188-07-8 sodium thiomethoxide 
• 14527-26-5 2-methylisothiourea sulphate 

Downstream Products

• 1068968-94-4 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid (6-methyl-3-oxo-2,5-dihydro-3H-[1,2,4]triazin-4-yl)-amide 
• 1068968-93-3 2-phenyoxy-pyrimidine-5-carboxylic acid N'-morpholin-4-yl-amide 
• 927803-27-8 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid 
• 927877-48-3 2-phenoxypyrimidine-5-carboxylic acid 
• 1068977-01-4 C₁₁H₇ClN₂O₂ 
• 1068975-32-5 2-phenoxy-pyrimidine-5-carboxylic acid methyl ester 
• 933989-25-4 2-cyano-4-methoxycarbonylpyrimidine 
• 1068975-33-6 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid methyl ester 
• 38275-49-9 methyl 2-(methylsulfonyl)pyrimidine-5-carboxylate 
• 323591-23-7 5-(bromomethyl)-2-(methylsulfanyl)pyrimidine 
• 19858-50-5 [2-(methylsulfanyl)-5-pyrimidinyl]methanol 

Relevant academic research and scientific papers

Reaction of esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate

The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0-5°C results in the nucleophilic substitution of readily eliminating groups (Cl, CH3O, CH3S) at the position 2 of the pyrimidine r

FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE

Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.

A general procedure for the synthesis of 2-substituted pyrimidine-5-carboxylic esters

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.