38275-41-1

Basic information

• Product Name: Methyl 2-(methylthio)pyrimidine-5-carboxylate
• Synonyms: METHYL 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE;METHYL 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 97;Methyl 2-(methylthio)pyrimidine-5-carboxylate 97%;Methyl 2-(methylsulfanyl)pyrimidine-5-carboxylate;Methyl 2-(methylsulphanyl)pyrimidine-5-carboxylate;Methyl 2-(methylsulphanyl)pyrimidine-5-carboxylate, 5-(Methoxycarbonyl)-2-(methylsulphanyl)pyrimidine;Methyl2-(methylsulphanyl)pyrimidine-5-carboxylate,tech;2-Methylthio-pyrimidine-5-carboxylic acid methyl ester
• CAS NO: 38275-41-1
• Molecular Formula: C₇H₈N₂O₂S
• Molecular Weight: 184.21562
• Product Categories: Heterocyclic Compound
• Mol File: 38275-41-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 96-97
• Boiling Point: 300.3 °C at 760 mmHg
• Flash Point: 135.4 °C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0.00113mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.86±0.22(Predicted)
• CAS DataBase Reference: Methyl 2-(methylthio)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(methylthio)pyrimidine-5-carboxylate(38275-41-1)
• EPA Substance Registry System: Methyl 2-(methylthio)pyrimidine-5-carboxylate(38275-41-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39
• RIDADR: UN 3335
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38275-41-1(Hazardous Substances Data)

Usage

Uses

Methyl 2-(Methylthio)pyrimidine-5-carboxylate is useful for preparation of pyrimidines by cyclocondensatiion of amidinium with formylpropenolate.

InChI:InChI=1/C7H8N2O2S/c1-11-6(10)5-3-8-7(12-2)9-4-5/h3-4H,1-2H3

Upstream product

• 14527-26-5 2-methylisothiourea sulphate 
• 287714-35-6 2-chloro-pyrimidine-5-carboxylic acid methyl ester 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 1068968-94-4 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid (6-methyl-3-oxo-2,5-dihydro-3H-[1,2,4]triazin-4-yl)-amide 
• 1068968-93-3 2-phenyoxy-pyrimidine-5-carboxylic acid N'-morpholin-4-yl-amide 
• 927803-27-8 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid 
• 927877-48-3 2-phenoxypyrimidine-5-carboxylic acid 
• 1068977-01-4 C₁₁H₇ClN₂O₂ 
• 1068975-32-5 2-phenoxy-pyrimidine-5-carboxylic acid methyl ester 
• 933989-25-4 2-cyano-4-methoxycarbonylpyrimidine 
• 323591-23-7 5-(bromomethyl)-2-(methylsulfanyl)pyrimidine 
• 19858-50-5 [2-(methylsulfanyl)-5-pyrimidinyl]methanol 
• 1068975-33-6 2-(3-methoxy-phenyl)-pyrimidine-5-carboxylic acid methyl ester 
• 38275-49-9 methyl 2-(methylsulfonyl)pyrimidine-5-carboxylate 

Relevant articles and documents

Reaction of esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate

The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0-5°C results in the nucleophilic substitution of readily eliminating groups (Cl, CH3O, CH3S) at the position 2 of the pyrimidine r

A general procedure for the synthesis of 2-substituted pyrimidine-5-carboxylic esters

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.