- PROCESSES FOR PRODUCING CARBOXYLIC ACIDS FROM FERMANTATION BROTHS CONTAINING THEIR AMMONIUM SALTS
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Process for the preparation of carboxylic acids like succinic acid (SA) from their correponding biologically-produced ammonium salts (like DAS) and / or amides and / or imides. The process involves reacting the biologically-produced derivatives at high temperature, removing ammonia and water, crystallizing the carboxylic acid obtained and recycling the mother liquor to the reaction system.
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Paragraph 0074
(2013/03/28)
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- PROCESSES FOR PRODUCING BUTANEDIOL AND DIAMINOBUTANE FROM FERMENTATION BROTHS CONTAINING AMMONIUM SUCCINATES
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Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt% water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid portion to produce nitrogen containing compounds such as diamine butane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN) or succinamide (DAM) and downstream products.
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Page/Page column 17-18
(2012/12/13)
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- PROCESSES FOR PRODUCING SUCCINIC ACID FROM FERMENTATION BROTHS CONTAINING DIAMMONIUM SUCCINATE
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Processes for making SA from either a clarified DAS-containing fermentation broth or a clarified MAS-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100°C to about 3000C to form an overhead that comprises water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt% water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.
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Page/Page column 11-13
(2011/10/13)
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- PROCESSES FOR PRODUCING DIAMINOBUTANE (DAB), SUCCINIC DINITRILE (SDN) AND SUCCINAMIDE (DAM)
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Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt% water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid portion to produce nitrogen containing compounds such as diamino butane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN) or succinamide (DAM) and downstream products.
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Page/Page column 14-15
(2011/12/04)
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- PROCESSES FOR THE PRODUCTION OF PYRROLIDONES
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Processes for making pyrrolidones include providing a clarified diammonium succinate (DAS)-containing and/or monoammonium succinate (MAS)-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of greater than 100°C to about 300°C to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt% water; cooling and/or evaporating the bottoms to attain a temperature and composition sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid SA portion to pyrrolidones.
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Page/Page column 18-19
(2011/12/04)
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- PROCESSES FOR THE PRODUCTION OF HYDROGENATED PRODUCTS
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A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.
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Page/Page column 7-8
(2011/10/13)
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- Processes for the production of tetrahydrofuran, gamma-butyrolactone and/or butanediol from salts of succinic acid
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A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of >100°C to about 300°C to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt% water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; recovering the solid portion; hydrogenating the solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product including at least one of THF, GBL or BDO; and recovering the hydrogenated product.
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Page/Page column 8; 9
(2011/10/13)
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- METHOD OF MANUFACTURING SUCCINIC ACID AND AMMONIUM SUCCINATE SOLUTIONS
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The present invention provides a method of manufacturing a highly pure ammonium succinate solution including the steps of (A) producing calcium succinate trihydrate by crystallization fermentation of a microorganism; (B) converting calcium succinate trihydrate to calcium succinate monohydrate by transition crystallization; (C) separating the calcium succinate monohydrate crystals; (D) substituting the calcium salt in the calcium succinate monohydrate with ammonium salt resulting in an ammonium succinate solution; and (E) removing the solid calcium carbonate from the ammonium succinate solution.
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Page/Page column 6-7
(2010/04/30)
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- METHOD FOR PRODUCING ORGANIC ACID
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A novel method is provided whereby a free organic acid can be produced particularly from an ammonium salt of an organic acid having a high melting point obtainable by bioconversion of a carbon source in the presence of a neutralizing agent, efficiently at a low cost, and the used material for reaction and a byproduct can be recycled for reuse without being disposed. An ammonium salt of organic acid A such as a dicarboxylic acid, a tricarboxylic acid or an amino acid is subjected to reactive crystallization by means of acid B such as a monocarboxylic acid satisfying the following formula (1), to separate free organic acid A in solid form:pKa(A) ≦ pKa(B) where pKa(A) and pKa(B) represent ionization indices of organic acid A and acid B, respectively, provided that when they have plural values, they represent the minimum pKa among them. The crystallization mother liquor after precipitating and separating organic acid A is, after separating acid B and then an ammonium salt of acid B, recycled for use in the reactive crystallization step. The ammonium salt of acid B is decomposed into acid B and ammonia, which are recycled for use in the reactive crystallization step and as a neutralizing agent in the bioconversion step, respectively.
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Page/Page column 25
(2008/06/13)
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