384830-08-4

Basic information

• Product Name: (3R)-3-(IodoMethyl)-1-Boc-piperidine
• Synonyms: (3R)-3-(IodoMethyl)-1-Boc-piperidine;(3R)-1-Boc-3-(iodomethyl)piperidine
• CAS NO: 384830-08-4
• Molecular Formula: C₁₁H₂₀INO₂
• Molecular Weight: 325.18647
• Mol File: 384830-08-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3R)-3-(IodoMethyl)-1-Boc-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-(IodoMethyl)-1-Boc-piperidine(384830-08-4)
• EPA Substance Registry System: (3R)-3-(IodoMethyl)-1-Boc-piperidine(384830-08-4)

Safety Data

• Hazardous Substances Data: 384830-08-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(3R)-3-(IodoMethyl)-1-Boc-piperidine is used as a building block for the preparation of various pharmaceutical compounds and bioactive molecules. The Boc group serves to protect the amine functionality of the piperidine ring, allowing for the introduction of new functionalities through the iodomethyl group, which can undergo various reactions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3R)-3-(IodoMethyl)-1-Boc-piperidine is utilized as a key intermediate for the development of new drugs. Its presence in drug-like molecules makes it a valuable component in the synthesis of potential therapeutic agents.
Used in Drug Discovery:
(3R)-3-(IodoMethyl)-1-Boc-piperidine plays a crucial role in drug discovery, as its versatile reactivity allows for the creation of diverse molecular structures with potential therapeutic properties. Researchers can exploit the compound's functional groups to design and synthesize novel drug candidates.

Upstream product

• 194726-40-4 (3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 25137-01-3 (R)-ethyl nipecotate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 384830-11-9 (2S,3R)-3-((S)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-1-carbonyl]-azetidine-2-carboxylic acid benzyl ester 
• 384830-10-8 (2S,3R)-3-((S)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 384830-09-5 (S)-3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.

Synthesis of potent and highly selective inhibitors of human tryptase

The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) as a potent inhibitor of human tryptase (IC503000-fold) for tryptase versus related serine proteases including trypsin.

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.