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116574-71-1

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116574-71-1 Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 116574-71-1 differently. You can refer to the following data:
1. (+/-)-1-Boc-3-(hydroxymethyl)piperidine is used as a reactant for synthesis of Pim-1 inhibitors, Vasopressin1b receptor antagonists, CXCR4 antagonists as anti-HIV agents, Amide CCR5 antagonist, PSSRI-based inhibitors of S. aureus multidrug efflux pumps and Human GnRH receptor antagonists.
2. Reactant for synthesis of:Pim-1 inhibitorsVasopressin1b receptor antagonistsCXCR4 antagonists as anti-HIV agentsAmide CCR5 antagonistPSSRI-based inhibitors of S. aureus multidrug efflux pumpsHuman GnRH receptor antagonists

Check Digit Verification of cas no

The CAS Registry Mumber 116574-71-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,5,7 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 116574-71:
(8*1)+(7*1)+(6*6)+(5*5)+(4*7)+(3*4)+(2*7)+(1*1)=131
131 % 10 = 1
So 116574-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3

116574-71-1 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H52784)  (±)-1-Boc-3-(hydroxymethyl)piperidine, 97%   

  • 116574-71-1

  • 5g

  • 1124.0CNY

  • Detail
  • Alfa Aesar

  • (H52784)  (±)-1-Boc-3-(hydroxymethyl)piperidine, 97%   

  • 116574-71-1

  • 25g

  • 4492.0CNY

  • Detail
  • Aldrich

  • (681318)  N-Boc-piperidine-3-methanol  97%

  • 116574-71-1

  • 681318-1G

  • 774.54CNY

  • Detail
  • Aldrich

  • (681318)  N-Boc-piperidine-3-methanol  97%

  • 116574-71-1

  • 681318-10G

  • 3,872.70CNY

  • Detail

116574-71-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Boc-piperidine-3-methanol

1.2 Other means of identification

Product number -
Other names tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:116574-71-1 SDS

116574-71-1Relevant articles and documents

Synthesis of substituted 1H-imidazol-1-ylmethylpiperidines. Facile separation of 1,4- and 1,5-disubstituted imidazoles

Rivera, Jocelyn,Jayasuriya, Nilukshi,Rane, Dinanath,Keertikar,Ferreira, J.Albert,Chao, Jianping,Minor, Keith,Guzi, Timothy

, p. 8917 - 8919 (2002)

The synthesis of several 1H-imidazol-1-ylmethylpiperidines is described. A method for the regioselective isolation of 1,4-disubstituted imidazoles utilizing the selective quaternization of the 1,5-disubstituted regioisomer was developed.

Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants

Zhu, Mei,Zhou, Huiyu,Ma, Ling,Dong, Biao,Zhou, Jinming,Zhang, Guoning,Wang, Minghua,Wang, Juxian,Cen, Shan,Wang, Yucheng

, (2021)

A novel class of HIV-1 protease inhibitors with flexible piperidine as the P2 ligand was designed with the aim of improving extensive interactions with the active subsites. Many inhibitors exhibited good to excellent inhibitory effect on enzymatic activity and viral infectivity. In particular, inhibitor 3a with (R)-piperidine-3-carboxamide as the P2 ligand and 4-methoxybenzenesulfonamide as the P2’ ligand showed an enzyme Ki value of 29 pM and antiviral IC50 value of 0.13 nM, more than six-fold enhancement of activity compared to DRV. Furthermore, there was no significant change in potency against DRV-resistant mutations and HIV-1NL4?3 variant for 3a. Besides, inhibitor 3a exhibited potent antiviral activity against subtype C variants with low nanomole EC50 values. In addition, the molecular modeling revealed important hydrogen bonds and other favorable van der Waals interactions with the backbone atoms of the protease and provided insight for designing and optimizing more potent HIV-1 protease inhibitors.

Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Caiger, Lewis,Constantin, Timothée,Douglas, James J.,Juliá, Fabio,Leonori, Daniele,Sheikh, Nadeem S.,Sinton, Conar

, p. 10448 - 10454 (2021/08/20)

Radical hydroxymethylation using formaldehyde as a C1 synthon is challenging due to the reversible and endothermic nature of the addition process. Here we report a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive. Halogen-atom transfer (XAT) from α-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh3. This event delivers a phosphoranyl radical that re-generates the alkyl radical and provides the hydroxymethylated product.

Palladium-catalyzed ring-closing reaction via C-N bond metathesis for rapid construction of saturated N-heterocycles

Yu, Bangkui,Zou, Suchen,Liu, Hongchi,Huang, Hanmin

, p. 18341 - 18345 (2020/11/17)

The ring-closing reactions based on chemical bond metathesis enable the efficient construction of a wide variety of cyclic systems which receive broad interest from medicinal and organic communities. However, the analogous reaction with C-N bond metathesis as a strategic fundamental step remains an unanswered challenge. Herein, we report the design of a new fundamental metallic C-N bond metathesis reaction that enables the palladium-catalyzed ring-closing reaction of aminodienes with aminals. The reactions proceed efficiently under mild conditions and exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5- to 16-membered N-heterocycles bearing diverse frameworks and functional groups.

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