The synthesis of substituted thio>acetic acids (6, thiamazins) is described.Various substituted 3(S)-(acylamino)-2-azetidinones were sulfenylated with tert-butyl (phtalimidothio)acetate.Deprotection of the tert-butyl ester with trifluoroacetic acid provided the title compounds.In sharp contrast to their oxygen analogues (oxamazins), the thiamazins were devoid of biological activity.
Woulfe, Steven R.,Miller, Marvin J.
p. 3133 - 3139
(2007/10/02)
Studies on the Preparation and Reactions of Tritylsulfenimines
Carbonyl compounds react with stable, crystalline triphenylmethanesulfenamide (TrSNH2, 4) under mild conditions to form tritylsulfenimines 5 and 6.Lithiation of acetone tritylsulfenimine (5c) at O deg C led to a novel rearrangement-decomposition producing
Branchaud, Bruce P.
p. 3531 - 3538
(2007/10/02)
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