- Novel pyrazole and indazole derivatives: Synthesis and evaluation of their anti-proliferative and anti-angiogenic activities
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The synthesis of several new pyrazole and indazole derivatives from acetophenone and tetralone substrates is reported. The bioactivities of the new compounds were evaluated through in vitro assays for endothelial cell proliferation and tube formation. Res
- Tzanetou, Evangelia,Liekens, Sandra,Kasiotis, Konstantinos M.,Fokialakis, Nikolas,Haroutounian, Serkos A.
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p. 804 - 811
(2013/01/15)
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- Nucleophilic acylation of α-haloketones with aldehydes: An umpolung strategy for the synthesis of 1,3-diketones
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The first example of N-heterocyclic carbene (NHC)-promoted intermolecular acylation of α-haloketones with aldehydes and α,β-unsaturated aldehydes (enals) is reported. The protocol involves carbonyl umpolung reactivity of aldehydes and enals in which the carbonyl carbon attacks nucleophilically on electrophilic terminal of α-haloketones to afford 1,3-diketones and α,β-unsaturated 1,3-diketones, respectively. Short reaction time, ambient temperature, operational simplicity, and high yields are the salient features of the present procedure.
- Singh, Santosh,Singh, Pankaj,Rai, Vijai K.,Kapoor, Ritu,Yadav, Lal Dhar S.
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experimental part
p. 125 - 128
(2011/02/26)
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- Boron difluoride β-diketonates: II. Synthesis of boron difluoride naphthoyl- and anisoylbenzoylmethanates substituted in the benzene ring
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Destructive acylation of copper(II) naphthoyl- and anisoylacetonates with substituted benzoyl chlorides yielded β-diketones containing two aromatic substituents. Their reaction with boron trifluoride etherate in the presence of tributyl borate gave the co
- Gukhman,Reutov
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p. 1608 - 1611
(2007/10/03)
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- Clemmensen reduction. XII The synthesis and acidolysis of some diaryl-substituted cyclopropane-1,2-diols. The possible involvement of a cyclopropyl cation
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The generation of a number of 1,2-diarylcyclopropane-1,2-diols is reported. Reaction of these in situ with acid gives, primarily, an α,β-unsaturated ketone in which the aryl substituent attached to the double bond is that which is best able to stabilize a benzylic cation. It is proposed that the reaction proceeds by O-protonation of the cyclopropane- 1,2-diol, followed by loss of water and opening of the resulting cyclopropyl cation and final deprotonation. Such initial O-protonation contrasts with the C-protonation normally observed in the acidolysis of cyclopropanols and other dialkyl- and alkylaryl-cyclopropane-1,2-diols.
- Davis, Brian R.,Hinds, Mark G.
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p. 309 - 319
(2007/10/03)
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