38502-65-7

Usage

Appearance

Yellow crystalline powder

Usage

Organic synthesis and pharmaceutical research

Functional groups

a. Two ketone functional groups
b. Methoxyphenyl group
c. Nitrophenyl group

Structural features

a. Central hydrocarbon chain
b. Methoxyphenyl and nitrophenyl groups attached to the chain

Classification

Diketone

Applications

a. Versatile intermediate in the synthesis of biologically active compounds
b. Synthesis of various pharmaceuticals

Pharmacological properties

a. Investigated for anti-inflammatory effects
b. Investigated for anti-tumor effects

Importance

a. Significant compound in medicinal chemistry research
b. Potential for development of new drugs and therapies

Upstream product

• 57026-78-5 3-(4-nitrophenyl)-1-(4-methoxyphenyl)-2,3-dibromo-1-propanone 
• 122-04-3 4-nitro-benzoyl chloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 555-16-8 4-nitrobenzaldehdye 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 122-84-9 4-methoxybenzyl methyl ketone 

Downstream Products

• 130956-72-8 β,4'-dimethoxy-4-nitro-trans-chalcone 
• 132593-65-8 β-ethoxy-4'-methoxy-4-nitro-trans-chalcone 
• 119701-65-4 2-(4-Methoxy-benzoyl)-5-(4-methoxy-phenyl)-1-(4-nitro-phenyl)-pentane-1,5-dione 
• 62-23-7 4-nitro-benzoic acid 
• 1428538-87-7 4-[3-(4-nitrophenyl)-1H-pyrazol-5-yl]phenol 
• 1428538-82-2 C₁₇H₁₄BrN₃O₃ 
• 888482-96-0 5-(4-methoxyphenyl)-3-(4-nitrophenyl)-1H-pyrazole 
• 748771-27-9 4-(5-(4-nitrophenyl)isoxazol-3-yl)phenol 

Relevant academic research and scientific papers

Novel pyrazole and indazole derivatives: Synthesis and evaluation of their anti-proliferative and anti-angiogenic activities

The synthesis of several new pyrazole and indazole derivatives from acetophenone and tetralone substrates is reported. The bioactivities of the new compounds were evaluated through in vitro assays for endothelial cell proliferation and tube formation. Res

Nucleophilic acylation of α-haloketones with aldehydes: An umpolung strategy for the synthesis of 1,3-diketones

The first example of N-heterocyclic carbene (NHC)-promoted intermolecular acylation of α-haloketones with aldehydes and α,β-unsaturated aldehydes (enals) is reported. The protocol involves carbonyl umpolung reactivity of aldehydes and enals in which the carbonyl carbon attacks nucleophilically on electrophilic terminal of α-haloketones to afford 1,3-diketones and α,β-unsaturated 1,3-diketones, respectively. Short reaction time, ambient temperature, operational simplicity, and high yields are the salient features of the present procedure.

Boron difluoride β-diketonates: II. Synthesis of boron difluoride naphthoyl- and anisoylbenzoylmethanates substituted in the benzene ring

Destructive acylation of copper(II) naphthoyl- and anisoylacetonates with substituted benzoyl chlorides yielded β-diketones containing two aromatic substituents. Their reaction with boron trifluoride etherate in the presence of tributyl borate gave the co

Clemmensen reduction. XII The synthesis and acidolysis of some diaryl-substituted cyclopropane-1,2-diols. The possible involvement of a cyclopropyl cation

The generation of a number of 1,2-diarylcyclopropane-1,2-diols is reported. Reaction of these in situ with acid gives, primarily, an α,β-unsaturated ketone in which the aryl substituent attached to the double bond is that which is best able to stabilize a benzylic cation. It is proposed that the reaction proceeds by O-protonation of the cyclopropane- 1,2-diol, followed by loss of water and opening of the resulting cyclopropyl cation and final deprotonation. Such initial O-protonation contrasts with the C-protonation normally observed in the acidolysis of cyclopropanols and other dialkyl- and alkylaryl-cyclopropane-1,2-diols.