385381-42-0

Basic information

• Product Name: 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID
• Synonyms: AKOS BBS-00000354;4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID;4-(4-METHYL-PIPERIDINE-1-SULFONYL)-BENZOIC ACID;IFLAB-BB F1386-0345;benzoic acid, 4-[(4-methyl-1-piperidinyl)sulfonyl]-
• CAS NO: 385381-42-0
• Molecular Formula: C13H17NO4S
• Molecular Weight: 283.34
• Mol File: 385381-42-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID(385381-42-0)
• EPA Substance Registry System: 4-[(4-METHYLPIPERIDIN-1-YL)SULFONYL]BENZOIC ACID(385381-42-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 385381-42-0(Hazardous Substances Data)

Upstream product

• 626-58-4 4-methylpiperidin 
• 10486-51-8 4-ethoxycarbonylbenzenesulfonyl chloride 

Relevant articles and documents

Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

A series of thiophene-benzenesulfonamide derivatives was designed and synthesized by exploring the structure-activity relationship of lead compounds 2,3-disubstituted thiophenes 25a and 297F as antituberculosis agents, which displayed potent antimycobacterial activity against drug-susceptible and clinically isolated drug-resistant tuberculosis. In particular, compound 17b, which had improved activity (minimum inhibitory concentration of 0.023 μg/mL) compared with the lead compounds, displayed good intracellular antimycobacterial activity in macrophages with a reduction of 1.29 log10 CFU. A druggability evaluation indicated that compound 17b had favorable hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. Moreover, compound 17b exhibited modest in vivo efficacy in an acute mouse model of tuberculosis. In addition, the molecular docking study elucidated the binding mode of compound 17b in the active site of DprE1. Therefore, compound 17b may be a promising antituberculosis lead for further research.

Diaryl 2- amide-substituted thiophene imide ester compound as well as preparation method and application thereof (by machine translation)

The invention also discloses a 2 - synthesis method thereof, and an application of the compound as an antibacterial agent, in the phthisis-caused by the bacterium, in particular to the, mycobacterium-induced infectious disease (especially (Tuberculosis,TB), mycobacterium- induced mycobacterium, tuberculosis), and (I) the invention, specifically relates to a pharmaceutical composition containing the compound of the present invention or, a R pharmaceutical composition comprising the compound of the present invention. 1 , R2 , R3 , R4 , R5 As described Y in the present invention. as described in the specification, the present invention is directed, to the preparation of novel compounds, having an anti-mycobacterial activity as potential, new drug (s) for the treatment (TB) or preventative treatment of infectious diseases, consisting of M. tuberculosis, in particular phthisis- caused by tubercular mycobacteria, while being useful in overcoming the problems associated with drug resistance. (by machine translation)