385802-40-4Relevant articles and documents
Direct substitution of arylalkynyl carbinols provides access to diverse terminal acetylene building blocks
G-Dayanandan, Narendran,Scocchera, Eric W.,Keshipeddy, Santosh,Jones, Heather F.,Anderson, Amy C.,Wright, Dennis L.
supporting information, p. 142 - 145 (2017/11/27)
To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereb
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
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Page/Page column 317, (2008/12/05)
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
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Page/Page column 317, (2008/12/05)
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened orhedgehog activity.
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
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Page/Page column 317; 391, (2008/12/05)
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened orhedgehog activity.
PROCESSES FOR THE PREPARATION OF COMPOUNDS
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Page/Page column 307, (2010/11/28)
The present invention provides improved synthetic methods for the preparation of compounds that modulate proliferation or differentiation in a cell or tissue.
PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES
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Page/Page column 20-21, (2008/06/13)
A compound of formula (I) wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.
Benzhydryl derivatives
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, (2008/06/13)
A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the
Discovery of an orally bioavailable NK1 receptor antagonist, (2s,3s)-(2- methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity
Ward,Armour,Bays,Evans,Giblin,Heron,Hubbard,Liang,Middlemiss,Mordaunt,Naylor,Pegg,Vinader,Watson,Bountra,Evans
, p. 4985 - 4992 (2007/10/03)
The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a medicinal chemistry program which initially identified a 3-furanyl analogue (6) with imp