387358-51-2

Basic information

• Product Name: 2-FLUORO-5-(METHYLSULFONYL)ANILINE
• Synonyms: 3-Amino-4-fluorophenyl methyl sulphone
• CAS NO: 387358-51-2
• Molecular Formula: C₇H₈FNO₂S
• Molecular Weight: 189.21
• Mol File: 387358-51-2.mol

Chemical Properties

• Melting Point: 70～72℃
• Boiling Point: 376.4°C at 760 mmHg
• Flash Point: 181.5°C
• Appearance: /
• Density: 1.374g/cm³
• Vapor Pressure: 7.25E-06mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 2-FLUORO-5-(METHYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-(METHYLSULFONYL)ANILINE(387358-51-2)
• EPA Substance Registry System: 2-FLUORO-5-(METHYLSULFONYL)ANILINE(387358-51-2)

Safety Data

• Hazardous Substances Data: 387358-51-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-(methylsulfonyl)aniline is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-5-(methylsulfonyl)aniline is employed as an intermediate for the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Chemical Compound Preparation:
2-Fluoro-5-(methylsulfonyl)aniline also serves as a building block in the preparation of a wide range of chemical compounds. Its versatile structure makes it a valuable component in the creation of new and innovative chemical entities for various applications across different industries.

InChI:InChI=1/C7H8FNO2S/c1-12(10,11)5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3

Upstream product

• 474710-08-2 C₂₀H₁₆FNO₂S 
• 453-72-5 1-fluoro-4-methanesulfonyl-2-nitrobenzene 

Downstream Products

• 474710-09-3 1-(2-fluoro-5-methylsulfonylphenyl)piperazine 
• 847148-17-8 2-chloro-1-fluoro-4-(methylsulfonyl)benzene 
• 1240287-19-7 1-fluoro-2-iodo-4-(methylsulfonyl)benzene 

Relevant articles and documents

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki 50 100 nM; PGD2-induced eosinophil shape change). Additional optimization of the PK characteristics led to the identification of several compounds suitable for in vivo testing. Of these, 19k and 19s were tested in two different pharmacological models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg).

PHENOXY ACETIC ACID DERIVATIVES

The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.