The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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Page/Page column 89
(2018/07/29)
Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones
Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.
Shcherbakova, Irina,Huang, Guangfei,Geoffroy, Otto J.,Nair, Satheesh K.,Swierczek, Krzysztof,Balandrin, Manuel F.,Fox, John,Heaton, William L.,Conklin, Rebecca L.
p. 2537 - 2540
(2007/10/03)
Syntheses of aromatic erythrina-alkaloids. XXII. Investigation of the rearranged product C 18 H 19 NO 3 , m. p. 174 degrees
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Mondon,Oelrich,Schickfluss
p. 2036 - 2046
(2007/10/04)
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