38853-85-9

Usage

Chemical structure

Contains a 1,4-dioxaspiro ring system

Type of compound

Carboxylic acid derivative

Medicinal chemistry

Building block for developing novel drug molecules

Pharmaceutical compounds

Valuable synthetic intermediate for preparation

Other fields

Materials science and organic synthesis

Drug discovery and development

Potential use in creating new drugs

Scientific and industrial applications

Broad range of possible uses due to unique structure and properties

Upstream product

• 23153-73-3 ethyl 1,4-dioxaspiro[4,4]nonane-6-carboxylate 
• 110295-58-4 1,4-dioxa-spiro[4.4]nonane-6-carboxylic acid methyl ester 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 

Downstream Products

• 854133-28-1 2-oxo-cyclopentanecarboxylic acid phenethyl-amide 
• 854133-39-4 2-amino-cyclopent-1-enecarboxylic acid phenethyl-amide 
• 854133-29-2 2-oxo-cyclopentanecarboxylic acid [2-(3-fluoro-phenyl)-ethyl]-amide 
• 854133-18-9 1,4-dioxa-spiro[4.4]nonane-6-carboxylic acid phenethyl-amide 
• 854133-40-7 2-amino-cyclopent-1-enecarboxylic acid [2-(3-fluoro-phenyl)-ethyl]-amide 
• 854133-19-0 1,4-dioxa-spiro[4.4]nonane-6-carboxylic acid [2-(3-fluoro-phenyl)-ethyl]-amide 
• 854133-50-9 acetic acid 2-(2-phenethylcarbamoyl-cyclopent-1-enylcarbamoyl)-phenyl ester 
• 854133-51-0 acetic acid 2-{2-[2-(3-fluoro-phenyl)-ethylcarbamoyl]-cyclopent-1-enylcarbamoyl}-phenyl ester 

Relevant academic research and scientific papers

HISTONE METHYLTRANSFERASE INHIBITORS

The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies (e.g., beta- thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.